Apelin, orexin-A and leptin plasma levels in morbid obesity and effect of gastric banding

被引:188
作者
Heinonen, MV
Purhonen, AK
Miettinen, P
Pääkkönen, M
Pirinen, E
Alhava, E
Åkerman, K
Herzig, KH
机构
[1] Univ Kuopio, Dept Biotechnol & Mol Med, AI Virtanen Inst Mol Sci, FIN-70211 Kuopio, Finland
[2] Univ Kuopio, Dept Neurobiol, AI Virtanen Inst Mol Sci, FIN-70211 Kuopio, Finland
[3] Univ Kuopio, Dept Surg, FIN-70211 Kuopio, Finland
[4] Univ Kuopio, Dept Pathol, FIN-70211 Kuopio, Finland
[5] Univ Kuopio, Dept Internal Med, KYS, FIN-70211 Kuopio, Finland
基金
芬兰科学院;
关键词
gastrointestinal peptides; morbid obesity; apelin; orexin-A; leptin;
D O I
10.1016/j.regpep.2005.05.003
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Maintenance of human energy homeostasis is regulated by a complex network. Peptides secreted from the gastrointestinal tract (GI) are signaling to the brain and other organs initiating or terminating food intake and energy expenditure. In the present study we investigated basal plasma levels of apelin, orexin-A, and leptin in morbid obese patients. In addition, we measured in a subgroup of these patients in the same individual orexin-A and leptin plasma levels one year after gastric banding surgery. Methods: Basal plasma values were determined in obese patients (BMI=48 +/- 1 kg/m(2) n=32) after an overnight fast and compared to healthy, normal weighted (BMI=22 +/- 2 kg/m(2) n=12) controls. In addition, blood samples were collected in a subgroup of patients (BMI=48 +/- 1 kg/m(2) n=8) the day before surgery and I year after the operation. Apelin, orexin-A, and leptin levels were analysed using ELISAs. Results: One year after the operation obese patients significantly lost weight (from 48 +/- 2 kg/m(2) to 39 +/- 2 kg/m(2); p < 0,001). Apelin, orexin-A and leptin levels in obese patients were significantly higher compared to control individuals (736 +/- 50 pg/ml vs. 174 +/- 14 pg/ml, p < 0.0001; 75.3 +/- 24.1 pg/ml vs. 0.8 +/- 0.4 pg/ml, p < 0.0001; 79.0 +/- 2.4 ng/ml vs. 5.8 +/- 0.8 ng/ml, p < 0.0001, respectively). Apelin and leptin plasma concentrations also correlated significantly with BMI (r=0.769, p < 0.0001; r=0.778;p < 0.0001, respectively), while orexin-A correlation was rather weak (r=0.335, p < 0.03). No difference between pre- and post-operative orexin-A levels was observed, while leptin plasma levels significantly decreased from 45.1 +/- 5.4 ng/ml to 27.3 +/- 6.0 ng/ml (p=0.015). Conclusions: Apelin, orexin-A, and leptin plasma levels correlated positively with the BMI. One year after gastric banding with significant loss in BMI basal plasma levels of leptin decreased, while orexin-A remained unchanged. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码:7 / 13
页数:7
相关论文
共 48 条
[1]   Decreased plasma orexin-A levels in obese individuals [J].
Adam, JA ;
Menheere, PPCA ;
van Dielen, FMH ;
Soeters, PB ;
Buurman, WA ;
Greve, JWM .
INTERNATIONAL JOURNAL OF OBESITY, 2002, 26 (02) :274-276
[2]   Leptin [J].
Ahima, RS ;
Flier, JS .
ANNUAL REVIEW OF PHYSIOLOGY, 2000, 62 :413-437
[3]   The role of leptin in regulating neuroendocrine function in humans [J].
Blüher, S ;
Mantzoros, CS .
JOURNAL OF NUTRITION, 2004, 134 (09) :2469S-2474S
[4]   Apelin, a newly identified adipokine up-regulated by insulin and obesity [J].
Boucher, J ;
Masri, B ;
Daviaud, D ;
Gesta, S ;
Guigné, C ;
Mazzucotelli, A ;
Castan-Laurell, I ;
Tack, I ;
Knibiehler, B ;
Carpéné, C ;
Audigier, Y ;
Saulnier-Blache, JS ;
Valet, P .
ENDOCRINOLOGY, 2005, 146 (04) :1764-1771
[5]   Bariatric surgery and long-term control of morbid obesity [J].
Brolin, RE .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 288 (22) :2793-2796
[6]   Localization of orexin-1 receptors to vagal afferent neurons in the rat and humans [J].
Burdyga, G ;
Lal, S ;
Spiller, D ;
Jiang, W ;
Thompson, D ;
Attwodd, S ;
Saeed, S ;
Grundy, D ;
Varro, A ;
Dimaline, R ;
Dockray, GJ .
GASTROENTEROLOGY, 2003, 124 (01) :129-139
[7]   Decreased plasma levels of orexin-A in sleep apnea [J].
Busquets, X ;
Barbé, F ;
Barceló, A ;
de la Peña, M ;
Sigritz, N ;
Mayoralas, LR ;
Ladaria, A ;
Agustí, A .
RESPIRATION, 2004, 71 (06) :575-579
[8]   Narcolepsy in orexin knockout mice:: Molecular genetics of sleep regulation [J].
Chemelli, RM ;
Willie, JT ;
Sinton, CM ;
Elmquist, JK ;
Scammell, T ;
Lee, C ;
Richardson, JA ;
Williams, SC ;
Xiong, YM ;
Kisanuki, Y ;
Fitch, TE ;
Nakazato, M ;
Hammer, RE ;
Saper, CB ;
Yanagisawa, M .
CELL, 1999, 98 (04) :437-451
[9]   Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction [J].
Chen, MM ;
Ashley, EA ;
Deng, DXF ;
Tsalenko, A ;
Deng, A ;
Tabibiazar, R ;
Ben-Dor, A ;
Fenster, B ;
Yang, E ;
King, JY ;
Fowler, M ;
Robbins, R ;
Johnson, FL ;
Bruhn, L ;
McDonagh, T ;
Dargie, H ;
Yakhini, Z ;
Tsao, PS ;
Quertermous, T .
CIRCULATION, 2003, 108 (12) :1432-1439
[10]  
De Falco M, 2002, IN VIVO, V16, P333