Transcription of essential cell division genes is linked to chromosome replication in Escherichia coli

被引：28
|
作者：
Liu, GW [1 ]
Begg, K [1 ]
Geddes, A [1 ]
Donachie, WD [1 ]
机构：
[1] Univ Edinburgh, Inst Cell & Mol Biol, Edinburgh EH9 3JR, Midlothian, Scotland
来源：
MOLECULAR MICROBIOLOGY | 2001年 / 40卷 / 04期
关键词：
D O I：
10.1046/j.1365-2958.2001.02434.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cell division normally follows the completion of each round of chromosome replication in Escherichia coli. Transcription of the essential cell division genes clustered at the mra region is shown here to depend on continuing chromosomal DNA replication. After chromosome replication was blocked by either nalidixic acid treatment or thymine starvation, the transcription of these cell division genes was repressed significantly. This suggests a way in which cell division is controlled by chromosome replication.
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页码：909 / 916
页数：8
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