Identification of two novel HLA-B40 alleles, B40:137 and B*40:158, in Taiwanese individuals

被引：3

作者：

Yang, K. L. ^{[1
,2
,3
]}

Lee, S. K. ^{[1
,2
]}

Chu, C. C. ^{[4
]}

Lin, C. C. ^{[1
,2
]}

Jiang, S. ^{[1
,2
]}

Chiu, H. M. ^{[1
,2
]}

Lin, S. ^{[1
,2
]}

Chen, Y. C. ^{[1
,2
]}

Chen, M. J. ^{[1
,2
]}

Jian, Y. F. ^{[1
,2
]}

Yang, C. F. ^{[1
,2
]}

Yang, S. Y. ^{[1
,2
]}

Shyr, M. H. ^{[1
,2
,5
]}

Lin, C. L. ^{[1
,2
]}

Lin, P. Y. ^{[1
,2
]}

机构：

[1] Buddhist Tzu Chi Gen Hosp, Chi Fdn, Immunogenet Lab, Buddhist Tzu Chi Stem Cells Ctr, Hualien 970, Taiwan

[2] Buddhist Tzu Chi Gen Hosp, Chi Fdn, Cord Blood Bank, Marrow Donor Registry, Hualien 970, Taiwan

[3] Buddhist Tzu Chi Univ, Dept Med Biotechnol, Relief Tzu Chi Fdn, Hualien 970, Taiwan

[4] Mackay Mem Hosp, Dept Med Res, Transfus Med Lab, Taipei, Taiwan

[5] Buddhist Tzu Chi Gen Hosp, Tzu Chi Fdn, Dept Anesthesiol, Hualien 970, Taiwan

来源：

INTERNATIONAL JOURNAL OF IMMUNOGENETICS | 2011年 / 38卷 / 04期

关键词：

LEUKOCYTE ANTIGEN-A; HAPLOTYPES;

D O I：

10.1111/j.1744-313X.2011.01001.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Using sequence-based typing method we discovered two new HLA-B*40 variants, B*40:137 and B*40:158, in Taiwanese individuals. The sequence of B*40:137 has three nucleotide (nt) changes from B*40:21 at nt 353 (C -> T), nt 355 (C -> A) and nt 369 (C -> T) resulting two coding changes at residue 94 (T -> I) and residue 95 (L -> I), whereas the sequence of B*40:158 differs from B*40:01:01 with five nt substitutes at nt 463 (C -> A), nt 477 (C -> G), nt 499 (T -> A), nt 512 (T -> G) and nt 527 (T -> A) causing five amino acid exchanges at codons 140 (Y -> S), 155 (R -> S), 168 (S -> T), 171 (L -> W) and 179 (V -> E). Our hypotheses on the generation of the two novel alleles are presented.

引用

页码：277 / 280

页数：4

共 29 条

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Identification of two novel HLA-B*40 alleles, B*40:137 and B*40:158, in Taiwanese individuals

Identification of two novel HLA-B40 alleles, B40:137 and B*40:158, in Taiwanese individuals