Identification of two novel HLA-B*40 alleles, B*40:137 and B*40:158, in Taiwanese individuals

被引：3
|
作者：
Yang, K. L. [1 ,2 ,3 ]
Lee, S. K. [1 ,2 ]
Chu, C. C. [4 ]
Lin, C. C. [1 ,2 ]
Jiang, S. [1 ,2 ]
Chiu, H. M. [1 ,2 ]
Lin, S. [1 ,2 ]
Chen, Y. C. [1 ,2 ]
Chen, M. J. [1 ,2 ]
Jian, Y. F. [1 ,2 ]
Yang, C. F. [1 ,2 ]
Yang, S. Y. [1 ,2 ]
Shyr, M. H. [1 ,2 ,5 ]
Lin, C. L. [1 ,2 ]
Lin, P. Y. [1 ,2 ]
机构：
[1] Buddhist Tzu Chi Gen Hosp, Chi Fdn, Immunogenet Lab, Buddhist Tzu Chi Stem Cells Ctr, Hualien 970, Taiwan
[2] Buddhist Tzu Chi Gen Hosp, Chi Fdn, Cord Blood Bank, Marrow Donor Registry, Hualien 970, Taiwan
[3] Buddhist Tzu Chi Univ, Dept Med Biotechnol, Relief Tzu Chi Fdn, Hualien 970, Taiwan
[4] Mackay Mem Hosp, Dept Med Res, Transfus Med Lab, Taipei, Taiwan
[5] Buddhist Tzu Chi Gen Hosp, Tzu Chi Fdn, Dept Anesthesiol, Hualien 970, Taiwan
来源：
INTERNATIONAL JOURNAL OF IMMUNOGENETICS | 2011年 / 38卷 / 04期
关键词：
LEUKOCYTE ANTIGEN-A; HAPLOTYPES;
D O I：
10.1111/j.1744-313X.2011.01001.x
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Using sequence-based typing method we discovered two new HLA-B*40 variants, B*40:137 and B*40:158, in Taiwanese individuals. The sequence of B*40:137 has three nucleotide (nt) changes from B*40:21 at nt 353 (C -> T), nt 355 (C -> A) and nt 369 (C -> T) resulting two coding changes at residue 94 (T -> I) and residue 95 (L -> I), whereas the sequence of B*40:158 differs from B*40:01:01 with five nt substitutes at nt 463 (C -> A), nt 477 (C -> G), nt 499 (T -> A), nt 512 (T -> G) and nt 527 (T -> A) causing five amino acid exchanges at codons 140 (Y -> S), 155 (R -> S), 168 (S -> T), 171 (L -> W) and 179 (V -> E). Our hypotheses on the generation of the two novel alleles are presented.
引用
收藏
页码：277 / 280
页数：4
相关论文
共 29 条
  • [1] Identification of the novel HLA allele, HLA-B*40:159, in a Taiwanese hematopoietic stem cell donor and the probable HLA haplotype in an association with B*40:159
    Yang, K. L.
    Lee, S. K.
    Lin, P. Y.
    INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 2012, 39 (06) : 520 - 523
  • [2] Detection of the rare HLA-B*40:97 allele in an unrelated Taiwanese bone marrow donor
    Yang, K. L.
    Lee, S. K.
    Kao, R. H.
    Lin, C. L.
    Lin, P. Y.
    INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 2012, 39 (06) : 527 - 529
  • [3] Identification of the novel HLA-B*40:221 allele in a Taiwanese hematopoietic stem cell donor using a sequence-based typing method
    Yang, K. L.
    Lee, S. K.
    Lin, P. Y.
    INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 2013, 40 (04) : 320 - 321
  • [4] Discovery of two novel HLA-B alleles, B*46:13:03 and B*15:189, in two Taiwanese volunteer bone marrow donors by sequence-based typing
    Yang, K. L.
    Lee, S. K.
    Lin, C. C.
    Jiang, S.
    Chiu, H. M.
    Lin, S.
    Chen, Y. C.
    Yang, S. Y.
    Jian, Y. F.
    Shyr, M. H.
    Lin, C. L.
    Lin, P. Y.
    INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 2011, 38 (06) : 539 - 542
  • [5] Discovery of a novel HLA-B*51 variant, B*51:112, in a Taiwanese bone marrow donor and identification of the plausible HLA haplotype in association with B*51:112
    Yang, K. L.
    Lee, S. K.
    Lin, P. Y.
    INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 2012, 39 (05) : 451 - 453
  • [6] Recognition of the three deduced probable human leukocyte antigen haplotypes in association with HLA-A* 31: 30 (A*31: 30-B*15-DRB1*14) and HLA-B*40:55 (A*02:07-B*40:55-DRB1*04:05 and A*26:01-B*40:55-DRB1*09:01) in a Taiwanese population
    Yang, Kuo-Liang
    Lin, Py-Yu
    TZU CHI MEDICAL JOURNAL, 2014, 26 (01): : 21 - 24
  • [7] Identification of the novel HLA-B*13:02:13 allele in a Taiwanese haematopoietic stem cell donor and the probable HLA haplotype in association with B*13:02:13
    Yang, K. L.
    Lee, S. K.
    Lin, P. Y.
    INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 2013, 40 (03) : 241 - 242
  • [8] Identification of a novel HLA-B*27 allele, B*27:79 and the B*27 subtype polymorphism in the Hunan ethnic Han population of China
    Xie, Y.
    Wang, S.
    Zuo, Z.
    Zhang, G.
    Cao, L.
    Li, T.
    INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 2013, 40 (06) : 524 - 527
  • [9] Characterization of the novel HLA-B allele, B*4621, in a Chinese individual
    Gao, S. -Q.
    Deng, Z. -H.
    Xu, Y. -P.
    TISSUE ANTIGENS, 2010, 75 (02): : 176 - 178
  • [10] Alu polymorphism within the MICB gene and association with HLA-B alleles
    Kulski, JK
    Dunn, DS
    Hui, J
    Martinez, P
    Romphruk, AV
    Leelayuwat, C
    Tay, GK
    Inoko, AOH
    IMMUNOGENETICS, 2002, 53 (10-11) : 975 - 979
123