Pestaloamides A and B, two spiro-heterocyclic alkaloid epimers from the plant endophytic fungus Pestalotiopsis sp. HS30

被引：7

作者：

Su, Xiao-Zheng ^{[1
,2
]}

Zhu, Yi-Ying ^{[1
]}

Tang, Jian-Wei ^{[1
]}

Hu, Kun ^{[1
]}

Li, Xiao-Nian ^{[1
]}

Sun, Han-Dong ^{[1
]}

Li, Yan ^{[1
]}

Puno, Pema-Tenzin ^{[1
]}

机构：

[1] Chinese Acad Sci, Yunnan Key Lab Nat Med Chem, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

SCIENCE CHINA-CHEMISTRY | 2020年 / 63卷 / 09期

基金：

中国国家自然科学基金;

关键词：

alkaloids; endophytic fungus; structure elucidation; tumor immunotherapy; IMMUNOTHERAPY; LIGANDS;

D O I：

10.1007/s11426-020-9762-0

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Pestaloamides A and B (1 and 2), two novel alkaloids featuring an unprecedented spiro[imidazothiazoledione-alkylidenecyclopentenone] scaffold, were obtained from the cultures of an endophytic fungus Pestalotiopsis sp. HS30 which inhabited the stems of Isodon xerophilus. Their planar structures and absolute configurations were fully determined by extensive spectroscopic analysis and X-ray crystallography. In addition, both compounds 1 and 2 showed the latent tumor immunotherapy activity through markedly promoting the cell surface engagement of NKG2D ligands involving MICA/B and ULBP1 in HCT116 cells.

引用

页码：1208 / 1213

页数：6

共 5 条

[1] Pestaloamides A and B, two spiro-heterocyclic alkaloid epimers from the plant endophytic fungus Pestalotiopsis sp. HS30
Xiao-Zheng Su
Yi-Ying Zhu
Jian-Wei Tang
Kun Hu
Xiao-Nian Li
Han-Dong Sun
Yan Li
Pema-Tenzin Puno
Science China Chemistry, 2020, 63 : 1208 - 1213
[2] Two New Pyrone Derivatives from the Plant Endophytic Fungus Exserohilum sp.
Li, Ruxin
Niu, Shubin
Guo, Liangdong
Zhang, Yang
NATURAL PRODUCT COMMUNICATIONS, 2014, 9 (10) : 1497 - 1498
[3] Arthrinins EG, Three Botryane Sesquiterpenoids from the Plant Endophytic Fungus Arthrinium sp. HS66
Su, Xiao-Zheng
Tang, Jian-Wei
Hu, Kun
Li, Xiao-Nian
Sun, Han-Dong
Puno, Pema-Tenzin
NATURAL PRODUCTS AND BIOPROSPECTING, 2020, 10 (04) : 201 - 207
[4] Arthrinins E–G, Three Botryane Sesquiterpenoids from the Plant Endophytic Fungus Arthrinium sp. HS66
Xiao-Zheng Su
Jian-Wei Tang
Kun Hu
Xiao-Nian Li
Han-Dong Sun
Pema-Tenzin Puno
Natural Products and Bioprospecting, 2020, 10 : 201 - 207
[5] Two new cytochalasins from the endophytic fungus Xylaria sp. GDGJ-77B
Xu, Zhao-Long
Li, Ben-Chao
Huang, Li-Li
Lv, Liu-Xia
Luo, Yan
Xu, Wei-Feng
Yang, Rui-Yun
NATURAL PRODUCT RESEARCH, 2024, 38 (09) : 1503 - 1509

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