Cryopreserved amniotic membrane in the treatment of diabetic foot ulcers: a case series

被引：0

作者：

Rodriguez Valiente, Monica ^{[1
,2
]}

Nicolas, Francisco J. ^{[3
]}

Garcia-Hernandez, Ana M. ^{[1
]}

Fuente Mora, Cristina ^{[1
]}

Blanquer, Miguel ^{[1
]}

Alcaraz, Patricio J. ^{[2
]}

Almansa, Sonia ^{[2
]}

Ruiz Merino, Guadalupe ^{[4
]}

Dolores Lopez Lucas, Ma ^{[1
]}

Alguero, Maria C. ^{[1
]}

Insausti, Carmen L. ^{[1
]}

Pinero, Antonio ^{[2
]}

Moraleda, Jose M. ^{[1
]}

Castellanos, Gregorio ^{[2
]}

机构：

[1] Hosp Clin Univ Virgen Arrixaca, Biomed Res Inst Murcia, Cell Therapy Unit, Inst Murciano Invest Biosanitaria,IMIB Arrixaca, El Palmer, Spain

[2] Hosp Clin Univ Virgen Arrixaca, Biomed Res Inst Murcia, Dept Gen Surg, Inst Murciano Invest Biosanitaria,IMIB Arrixaca, El Palmer, Spain

[3] Hosp Clin Univ Virgen Arrixaca, Biomed Res Inst Murcia, Inst Murciano Invest Biosanitaria, Mol Oncol & TGFB,Res Unit,IMIB Arrixaca, El Palmer, Spain

[4] Hosp Clin Univ Virgen Arrixaca, Biomed Res Inst Murcia, Inst Murciano Invest Biosanitaria, FFIS Reg Murcia,Support Res Unit,IMIB Arrixaca, El Palmer, Spain

来源：

JOURNAL OF WOUND CARE | 2018年 / 27卷 / 12期

关键词：

amniotic membrane; cryopreservation; diabetic foot ulcer; wound healing; CHRONIC WOUNDS; GROWTH-FACTOR; CELLS; TRANSPLANTATION; MANAGEMENT; ALLOGRAFTS; ANGIOGENESIS; SUPPRESSION;

D O I：

暂无

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Objective: The amniotic membrane (AM) is a tissue with low immunogenity and high therapeutic potential due to its anti- inflammatory, anti-fibrotic and antimicrobial effects. This paper describes the use of cryopreserved amniotic membrane allografts to treat diabetic foot ulcers (DFUs) in patients with diabetes. Method: In this case series, AM was processed to obtain a final medicinal product: cryopreserved amniotic membrane. cryopreserved AM was applied every 7-10 days until total epithelialisation of the DFUs. Results: A total of 14 patients with DFUs (median size: 12.30cm, (range: 0.52-42.5cm(2)) were treated and followed up until complete closure (median time: 20 weeks, range: 7-56 weeks). Patients received 4-40 AM applications. All patients in this study achieved complete epithelialisation of the wound. No adverse events were observed. Conclusion: AM is a feasible and safe treatment in complex DFUs. Furthermore, the treatment is successful in achieving epithelialisation of long-evolution, unhealed wounds resistant to conventional therapies.

引用

页码：806 / 815

页数：10

共 47 条

[1] Amniotic Membrane Modifies the Genetic Program Induced by TGFβ, Stimulating Keratinocyte Proliferation and Migration in Chronic Wounds [J].

Alcaraz, Antonia ;

Mrowiec, Anna ;

Luisa Insausti, Carmen ;

Bernabe-Garcia, Angel ;

Maria Garcia-Vizcaino, Eva ;

Concepcion Lopez-Martinez, Maria ;

Monfort, Asuncion ;

Izeta, Ander ;

Maria Moraleda, Jose ;

Castellanos, Gregorio ;

Jose Nicolas, Francisco .

PLOS ONE, 2015, 10 (08)

[2] Amniotic Membrane Transplantation in the Treatment of Chronic Lower Limb Ulcers [J].

Alsina-Gibert, M. ;

Pedregosa-Fauste, S. .

ACTAS DERMO-SIFILIOGRAFICAS, 2012, 103 (07) :608-613

[3] Wound management of chronic diabetic foot ulcers: From the basics to regenerative medicine [J].

Andrews, Karen L. ;

Houdek, Matthew T. ;

Kiemele, Lester J. .

PROSTHETICS AND ORTHOTICS INTERNATIONAL, 2015, 39 (01) :29-39

[4] The molecular biology of chronic wounds and delayed healing in diabetes [J].

Blakytny, R. ;

Jude, E. .

DIABETIC MEDICINE, 2006, 23 (06) :594-608

[5]

Mompo JIB, 2011, REV ESP QUIM, V24, P233

[6]

Datta Himadri, 2004, J Indian Med Assoc, V102, P726

[7]

Dunford C, 1999, J Wound Care, V8, P506

[8]

Eskandarlou M, 2016, WORLD J PLAST SURG, V5, P39

[9] The clinical applications of human amnion in plastic surgery [J].

Fairbairn, N. G. ;

Randolph, M. A. ;

Redmond, R. W. .

JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, 2014, 67 (05) :662-675

[10] Dehydrated amniotic membrane allografts for the treatment of chronic wounds: a case series [J].

Forbes, J. ;

Fetterolf, D. E. .

JOURNAL OF WOUND CARE, 2012, 21 (06) :290-+

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