The role of trace metallic elements in neurodegenerative disorders: Quantitative analysis using XRF and XANES spectroscopy

被引：35
作者：
Ide-Ektessabi, A [1 ]
Rabionet, M [1 ]
机构：
[1] Kyoto Univ, Inst Innovat Ctr, Sakyo Ku, Kyoto 6068501, Japan
来源：
ANALYTICAL SCIENCES | 2005年 / 21卷 / 07期
关键词：
D O I：
10.2116/analsci.21.885
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The present paper focuses on the analysis of trace metallic elements and their role in neurodegenerative disorders. The use of synchrotron radiation microbeams allows investigation of pathological tissues from Alzheimer's disease, Parkinson's disease and Amyotrophic lateral sclerosis cases in a nondestructive manner and at cellular level. By employing X-ray absorption near edge structure (XANES) technique, the chemical state of the investigated elements can be determined, while energy-selective X-ray fluorescence spectroscopy provides the spatial distribution of each element in each oxidative state selectively. The investigated tissues (derived from human, monkey and mouse specimens) show distinct imbalances of metallic elements such as Zn and Cu as well as Fe2+/Fe3+ redox pair, which point to oxidative stress as a crucial factor in the development or progress of these neurodegenerative diseases.
引用
收藏
页码：885 / 892
页数：8
相关论文
共 37 条
  • [1] Ubiquitin, cellular inclusions and their role in neurodegeneration
    Alves-Rodrigues, A
    Gregori, L
    Figueiredo-Pereira, ME
    [J]. TRENDS IN NEUROSCIENCES, 1998, 21 (12) : 516 - 520
  • [2] Dramatic aggregation of Alzheimer Aβ by Cu(II) is induced by conditions representing physiological acidosis
    Atwood, CS
    Moir, RD
    Huang, XD
    Scarpa, RC
    Bacarra, NME
    Romano, DM
    Hartshorn, MK
    Tanzi, RE
    Bush, AI
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (21) : 12817 - 12826
  • [3] Neurodegenerative diseases and oxidative stress
    Barnham, KJ
    Masters, CL
    Bush, AI
    [J]. NATURE REVIEWS DRUG DISCOVERY, 2004, 3 (03) : 205 - 214
  • [4] Superoxide dismutase and the death of motoneurons in ALS
    Beckman, JS
    Estévez, AG
    Crow, JR
    [J]. TRENDS IN NEUROSCIENCES, 2001, 24 (11) : S15 - S20
  • [5] Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1
    Bruijn, LI
    Houseweart, MK
    Kato, S
    Anderson, KL
    Anderson, SD
    Ohama, E
    Reaume, AG
    Scott, RW
    Cleveland, DW
    [J]. SCIENCE, 1998, 281 (5384) : 1851 - 1854
  • [6] Metals and neuroscience
    Bush, AI
    [J]. CURRENT OPINION IN CHEMICAL BIOLOGY, 2000, 4 (02) : 184 - 191
  • [7] Villus and crypt cell composition in the secreting mouse jejunum measured with x-ray microanalysis
    Butt, AG
    Bowler, JM
    McLaughlin, CW
    [J]. JOURNAL OF MEMBRANE BIOLOGY, 1998, 162 (01) : 17 - 29
  • [8] Neurodegeneration in amyotrophic lateral sclerosis:: the role of oxidative stress and altered homeostasis of metals
    Carrì, MT
    Ferri, A
    Cozzolino, M
    Calabrese, L
    Rotilio, G
    [J]. BRAIN RESEARCH BULLETIN, 2003, 61 (04) : 365 - 374
  • [9] CASH A, 2004, MED CHEM REV, V1, P19
  • [10] ZINC NEUROTOXICITY IN CORTICAL CELL-CULTURE
    CHOI, DW
    YOKOYAMA, M
    KOH, J
    [J]. NEUROSCIENCE, 1988, 24 (01) : 67 - 79
1234