Intracellular Enzyme-Responsive Profluorophore and Prodrug Nanoparticles for Tumor-Specific Imaging and Precise Chemotherapy

被引：21
|
作者：
Pei, Qing [1 ]
Lu, Shaojin [1 ,2 ]
Zhou, Junli [1 ,2 ]
Jiang, Bowen [1 ,2 ]
Li, Chaonan [1 ,2 ]
Xie, Zhigang [1 ,2 ]
Jing, Xiabin [1 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China
[2] Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China
来源：
ACS APPLIED MATERIALS & INTERFACES | 2021年 / 13卷 / 50期
基金：
中国国家自然科学基金;
关键词：
NQO1; prodrug; enzyme; precise therapy; near-infrared imaging; DRUG; CHEMISTRY; DESIGN; MITOCHONDRIA; DIAGNOSIS; MICELLES; EFFICACY; PROBES;
D O I：
10.1021/acsami.1c19058
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Responsive drug delivery systems possess great potential in disease diagnosis and treatment. Herein, we develop an activatable prodrug and fluorescence imaging material by engineering the endogenous NAD(P)-H:quinone oxidoreductase-1 (NQO1) responsive linker. The as-prepared nanomaterials possess the NQO1-switched drug release and fluorescence enablement, which realizes the tumor-specific chemotherapy and imaging in living mice. The enzyme-sensitive prodrug nanoparticles exhibit selectively potent anticancer performance to NQO1-positive cancer and ignorable off-target toxicity. This work provides an alternative strategy for constructing smart prodrug nanoplatforms with precision, selectivity, and practicability for advanced cancer imaging and therapy.
引用
收藏
页码：59708 / 59719
页数：12
相关论文
共 50 条
  • [41] Amphiphilic hyaluronic acid-based nanoparticles for tumor-specific optical/MR dual imaging
    Lee, Dong-Eun
    Kim, Ah Young
    Yoon, Hong Yeol
    Choi, Ki Young
    Kwon, Ick Chan
    Jeong, Seo Young
    Park, Jae Hyung
    Kim, Kwangmeyung
    JOURNAL OF MATERIALS CHEMISTRY, 2012, 22 (21) : 10444 - 10447
  • [42] Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging
    Bartlett, Derek W.
    Su, Helen
    Hildebrandt, Isabel J.
    Weber, Wolfgang A.
    Davis, Mark E.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (39) : 15549 - 15554
  • [43] Ultrasmall mesoporous organosilica nanoparticles: Morphology modulations and redox-responsive biodegradability for tumor-specific drug delivery
    Yu, Luodan
    Chen, Yu
    Lin, Han
    Du, Wenxian
    Chen, Hangrong
    Shi, Jianlin
    BIOMATERIALS, 2018, 161 : 292 - 305
  • [44] Polymeric prodrug microspheres with tumor intracellular microenvironment bioreducible degradation, pH-triggered "off-on" fluorescence and drug release for precise imaging-guided diagnosis and chemotherapy
    Pei, Mingliang
    Li, Guoping
    Ma, Kangwei
    Li, Jianan
    Wang, Yuanfan
    Liu, Peng
    COLLOIDS AND SURFACES B-BIOINTERFACES, 2019, 177 : 313 - 320
  • [45] A ZIF-90 nanoplatform loaded with an enzyme-responsive organic small-molecule probe for imaging the hypoxia status of tumor cells
    Zou, Ruifen
    Gong, Qiuyu
    Shi, Zhenzhi
    Zheng, Jianping
    Xing, Jie
    Liu, Chuang
    Jiang, Zhenqi
    Wu, Aiguo
    NANOSCALE, 2020, 12 (27) : 14870 - 14881
  • [46] Highly Stable Silica-Coated Bismuth Nanoparticles Deliver Tumor Microenvironment-Responsive Prodrugs to Enhance Tumor-Specific Photoradiotherapy
    Xiang, Huandong
    Wu, Yuanzheng
    Zhu, Xianyu
    She, Mengyao
    An, Qi
    Zhou, Ruyi
    Xu, Peng
    Zhao, Feng
    Yan, Liang
    Zhao, Yuliang
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2021, 143 (30) : 11449 - 11461
  • [47] In vivo Preclinical Tumor-Specific Imaging of Superparamagnetic Iron Oxide Nanoparticles Using Magnetic Particle Imaging for Cancer Diagnosis
    Park, Sang-Jin
    Han, Seung Ro
    Kang, Yun Hee
    Lee, Eun-Jin
    Kim, Eu-Gene
    Hong, Hyobong
    Jeong, Jae-Chan
    Lee, Myung-Shin
    Lee, Seung-Hoon
    Song, Dae-Yong
    INTERNATIONAL JOURNAL OF NANOMEDICINE, 2022, 17 : 3711 - 3722
  • [48] Applications of Cu2+-Loaded Silica Nanoparticles to Photothermal Therapy and Tumor-Specific Fluorescence Imaging
    Park, Ji-Ho
    Sung, Yejin
    Jo, SeongHoon
    Lee, Seung Ho
    Ryu, Ju Hee
    Sun, In-Cheol
    Ahn, Cheol-Hee
    JOURNAL OF FUNCTIONAL BIOMATERIALS, 2024, 15 (04)
  • [49] pH-responsive intramolecular FRET-based self-tracking polymer prodrug nanoparticles for real-time tumor intracellular drug release monitoring and imaging
    Dong, Yuman
    Du, Pengcheng
    Liu, Peng
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2020, 588
  • [50] Reduction/Oxidation-Responsive Hierarchical Nanoparticles with Self-Driven Degradability for Enhanced Tumor Penetration and Precise Chemotherapy
    Yin, Shaoping
    Gao, Yi
    Zhang, Yu
    Xu, Jianan
    Zhu, Jianping
    Zhou, Fang
    Gu, Xiaochen
    Wang, Guangji
    Li, Juan
    ACS APPLIED MATERIALS & INTERFACES, 2020, 12 (16) : 18273 - 18291
12345