Intracellular Enzyme-Responsive Profluorophore and Prodrug Nanoparticles for Tumor-Specific Imaging and Precise Chemotherapy

被引：21
|
作者：
Pei, Qing [1 ]
Lu, Shaojin [1 ,2 ]
Zhou, Junli [1 ,2 ]
Jiang, Bowen [1 ,2 ]
Li, Chaonan [1 ,2 ]
Xie, Zhigang [1 ,2 ]
Jing, Xiabin [1 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China
[2] Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China
来源：
ACS APPLIED MATERIALS & INTERFACES | 2021年 / 13卷 / 50期
基金：
中国国家自然科学基金;
关键词：
NQO1; prodrug; enzyme; precise therapy; near-infrared imaging; DRUG; CHEMISTRY; DESIGN; MITOCHONDRIA; DIAGNOSIS; MICELLES; EFFICACY; PROBES;
D O I：
10.1021/acsami.1c19058
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Responsive drug delivery systems possess great potential in disease diagnosis and treatment. Herein, we develop an activatable prodrug and fluorescence imaging material by engineering the endogenous NAD(P)-H:quinone oxidoreductase-1 (NQO1) responsive linker. The as-prepared nanomaterials possess the NQO1-switched drug release and fluorescence enablement, which realizes the tumor-specific chemotherapy and imaging in living mice. The enzyme-sensitive prodrug nanoparticles exhibit selectively potent anticancer performance to NQO1-positive cancer and ignorable off-target toxicity. This work provides an alternative strategy for constructing smart prodrug nanoplatforms with precision, selectivity, and practicability for advanced cancer imaging and therapy.
引用
收藏
页码：59708 / 59719
页数：12
相关论文
共 50 条
  • [31] Multifunctional small-molecule theranostic agents for tumor-specific imaging and targeted chemotherapy
    Zhang, Renshuai
    Hao, Li
    Chen, Pengwei
    Zhang, Gang
    Liu, Ning
    BIOORGANIC CHEMISTRY, 2023, 137
  • [32] Azo-based small molecular hypoxia responsive theranostic for tumor-specific imaging and therapy
    Zhou, Ying
    Maiti, Mrinmoy
    Sharma, Amit
    Won, Miae
    Yu, Le
    Miao, Lan Xi
    Shin, Jinwoo
    Podder, Arup
    Bobba, Kondapa Naidu
    Han, Jiyou
    Bhuniya, Sankarprasad
    Kim, Jong Seung
    JOURNAL OF CONTROLLED RELEASE, 2018, 288 : 14 - 22
  • [33] Antigen-responsive molecular sensor enables real-time tumor-specific imaging
    Kim, Hyunjin
    Choi, Hak Soo
    Kim, Seok-Ki
    Lee, Byung Il
    Choi, Yongdoo
    THERANOSTICS, 2017, 7 (04): : 952 - 961
  • [34] Fluorescent carbon quantum dots-based prodrug nanosponges with outstanding tumor-specific drug delivery and imaging
    Chen, Wei
    Liu, Peng
    ADVANCED POWDER TECHNOLOGY, 2022, 33 (11)
  • [35] Hypoxia-responsive nanoparticles for tumor-specific starvation therapy via a two-pronged approach
    Yang, Nan
    Cao, Changyu
    Xu, Chengshuang
    Su, Yan
    Wang, Wenjun
    Song, Xuejiao
    Liang, Chen
    Dong, Xiaochen
    Mou, Xiaozhou
    CHEMICAL ENGINEERING JOURNAL, 2024, 485
  • [36] Tumor-specific activatable biopolymer nanoparticles stabilized by hydroxyethyl starch prodrug for self-amplified cooperative cancer therapy
    Xiong, Yuxuan
    Wang, Zibing
    Wang, Qiang
    Deng, Qingyuan
    Chen, Jitang
    Wei, Jianshuang
    Yang, Xiaoquan
    Yang, Xiangliang
    Li, Zifu
    THERANOSTICS, 2022, 12 (02): : 944 - 962
  • [37] Enzyme-responsive mannose-grafted magnetic nanoparticles for breast and liver cancer therapy and tumor-associated macrophage immunomodulation
    Darya, Gholam Hossein
    Zare, Omid
    Karbalaei-Heidari, Hamid Reza
    Zeinali, Sedighe
    Sheardown, Heather
    Rastegari, Banafsheh
    EXPERT OPINION ON DRUG DELIVERY, 2024, 21 (04) : 663 - 677
  • [38] Versatile Prodrug Nanoparticles for Acid-Triggered Precise Imaging and Organelle-Specific Combination Cancer Therapy
    Feng, Bing
    Zhou, Fangyuan
    Xu, Zhiai
    Wang, Tingting
    Wang, Dangge
    Liu, Jianping
    Fu, Yuanlei
    Yin, Qi
    Zhang, Zhiwen
    Yu, Haijun
    Li, Yaping
    ADVANCED FUNCTIONAL MATERIALS, 2016, 26 (41) : 7431 - 7442
  • [39] Enzyme/pH Dual-Responsive Engineered Nanoparticles for Improved Tumor Immuno-Chemotherapy
    Liu, Zefeng
    Hao, Xiaohan
    Qian, Jieying
    Zhang, Hao
    Bao, Hui
    Yang, Qiong
    Gu, Weiguang
    Huang, Xiaowan
    Zhang, Yunjiao
    ACS APPLIED MATERIALS & INTERFACES, 2024, 16 (10) : 12951 - 12964
  • [40] A novel ROS-activable self-immolative prodrug for tumor-specific amplification of oxidative stress and enhancing chemotherapy of mitoxantrone
    Zhang, Hongjie
    Chen, Weijian
    Wang, Jing
    Du, Wenxiang
    Wang, Bibo
    Song, Lei
    Hu, Yuan
    Ma, Xiaopeng
    BIOMATERIALS, 2023, 293
12345