Intracellular Enzyme-Responsive Profluorophore and Prodrug Nanoparticles for Tumor-Specific Imaging and Precise Chemotherapy

被引：21
|
作者：
Pei, Qing [1 ]
Lu, Shaojin [1 ,2 ]
Zhou, Junli [1 ,2 ]
Jiang, Bowen [1 ,2 ]
Li, Chaonan [1 ,2 ]
Xie, Zhigang [1 ,2 ]
Jing, Xiabin [1 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China
[2] Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China
来源：
ACS APPLIED MATERIALS & INTERFACES | 2021年 / 13卷 / 50期
基金：
中国国家自然科学基金;
关键词：
NQO1; prodrug; enzyme; precise therapy; near-infrared imaging; DRUG; CHEMISTRY; DESIGN; MITOCHONDRIA; DIAGNOSIS; MICELLES; EFFICACY; PROBES;
D O I：
10.1021/acsami.1c19058
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Responsive drug delivery systems possess great potential in disease diagnosis and treatment. Herein, we develop an activatable prodrug and fluorescence imaging material by engineering the endogenous NAD(P)-H:quinone oxidoreductase-1 (NQO1) responsive linker. The as-prepared nanomaterials possess the NQO1-switched drug release and fluorescence enablement, which realizes the tumor-specific chemotherapy and imaging in living mice. The enzyme-sensitive prodrug nanoparticles exhibit selectively potent anticancer performance to NQO1-positive cancer and ignorable off-target toxicity. This work provides an alternative strategy for constructing smart prodrug nanoplatforms with precision, selectivity, and practicability for advanced cancer imaging and therapy.
引用
收藏
页码：59708 / 59719
页数：12
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