Intracellular Enzyme-Responsive Profluorophore and Prodrug Nanoparticles for Tumor-Specific Imaging and Precise Chemotherapy

被引：23
|
作者：
Pei, Qing [1 ]
Lu, Shaojin [1 ,2 ]
Zhou, Junli [1 ,2 ]
Jiang, Bowen [1 ,2 ]
Li, Chaonan [1 ,2 ]
Xie, Zhigang [1 ,2 ]
Jing, Xiabin [1 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China
[2] Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China
来源：
ACS APPLIED MATERIALS & INTERFACES | 2021年 / 13卷 / 50期
基金：
中国国家自然科学基金;
关键词：
NQO1; prodrug; enzyme; precise therapy; near-infrared imaging; DRUG; CHEMISTRY; DESIGN; MITOCHONDRIA; DIAGNOSIS; MICELLES; EFFICACY; PROBES;
D O I：
10.1021/acsami.1c19058
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Responsive drug delivery systems possess great potential in disease diagnosis and treatment. Herein, we develop an activatable prodrug and fluorescence imaging material by engineering the endogenous NAD(P)-H:quinone oxidoreductase-1 (NQO1) responsive linker. The as-prepared nanomaterials possess the NQO1-switched drug release and fluorescence enablement, which realizes the tumor-specific chemotherapy and imaging in living mice. The enzyme-sensitive prodrug nanoparticles exhibit selectively potent anticancer performance to NQO1-positive cancer and ignorable off-target toxicity. This work provides an alternative strategy for constructing smart prodrug nanoplatforms with precision, selectivity, and practicability for advanced cancer imaging and therapy.
引用
收藏
页码：59708 / 59719
页数：12
相关论文
共 23 条
  • [1] Enzyme-Responsive Copolymer as a Theranostic Prodrug for Tumor In Vivo Imaging and Efficient Chemotherapy
    Wang, Bing
    Lv, Peilin
    Cai, Hao
    Li, Yaying
    Zhu, Hongyan
    Lui, Su
    Gong, Qiyong
    Luo, Kui
    JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2019, 15 (09) : 1897 - 1908
  • [2] An intracellular enzyme-responsive polymeric prodrug with synergistic effect of chemotherapy and two-photon photodynamic therapy
    Luo, Lei
    Yin, Zhen
    Qi, Yiming
    Liu, Shuang
    Yi, Yong
    Tian, Xiaohe
    Wu, Yahui
    Zhong, Dan
    Gu, Zhongwei
    Zhang, Hu
    Luo, Kui
    APPLIED MATERIALS TODAY, 2021, 23
  • [3] Tumor-Specific Monomethyl Auristatin E (MMAE) Prodrug Nanoparticles for Safe and Effective Chemotherapy
    Cho, Hanhee
    Shim, Man Kyu
    Moon, Yujeong
    Song, Sukyung
    Kim, Jinseong
    Choi, Jiwoong
    Kim, Jeongrae
    Lee, Youngjoo
    Park, Jung Yeon
    Kim, Yongju
    Ahn, Cheol-Hee
    Kim, Mi Ra
    Yoon, Hong Yeol
    Kim, Kwangmeyung
    PHARMACEUTICS, 2022, 14 (10)
  • [4] Enzyme-Responsive Nanoparticles for Anti-tumor Drug Delivery
    Li, Mengqian
    Zhao, Guangkuo
    Su, Wei-Ke
    Shuai, Qi
    FRONTIERS IN CHEMISTRY, 2020, 8
  • [5] Facile preparation of pH/reduction dual-responsive prodrug nanohydrogels for tumor-specific intracellular triggered release with enhanced anticancer efficiency
    Zhou, Tingting
    Jia, Xu
    Zhao, Xubo
    Li, Jiagen
    Liu, Peng
    JOURNAL OF MATERIALS CHEMISTRY B, 2017, 5 (15) : 2840 - 2848
  • [6] Responsive Prodrug Self-Assembled Vesicles for Targeted Chemotherapy in Combination with Intracellular Imaging
    Chen, Hongzhong
    Tham, Huijun Phoebe
    Ang, Chung Yen
    Qu, Qiuyu
    Zhao, Lingzhi
    Xing, Pengyao
    Bai, Linyi
    Tan, Si Yu
    Zhao, Yanli
    ACS APPLIED MATERIALS & INTERFACES, 2016, 8 (37) : 24319 - 24324
  • [7] Enzyme-responsive fluorescent camptothecin prodrug/polysaccharide supramolecular assembly for targeted cellular imaging and in situ controlled drug release
    Zhang, Yu-Hui
    Zhang, Ying-Ming
    Sheng, Xianliang
    Wang, Jie
    Liu, Yu
    CHEMICAL COMMUNICATIONS, 2020, 56 (07) : 1042 - 1045
  • [8] Radiation responsive PROTAC nanoparticles for tumor-specific proteolysis enhanced radiotherapy
    Xu, Mengxia
    Yun, Yuyang
    Li, Changjun
    Ruan, Yiling
    Muraoka, Osamu
    Xie, Weijia
    Sun, Xiaolian
    JOURNAL OF MATERIALS CHEMISTRY B, 2024, 12 (13)
  • [9] A tumor-specific ROS self-supply enhanced cascade-responsive prodrug activation nanosystem for amplified chemotherapy against multidrug-resistant tumors
    Wang, Jing
    Zhang, Hanxi
    Lv, Jiazhen
    Zheng, Yue
    Li, Mengyue
    Yang, Geng
    Wei, Xiaodan
    Li, Ningxi
    Huang, Honglin
    Li, Tingting
    Qin, Xiang
    Li, Shun
    Wu, Chunhui
    Zhang, Wei
    Liu, Yiyao
    Yang, Hong
    ACTA BIOMATERIALIA, 2023, 164 : 522 - 537
  • [10] Multifunctional small-molecule theranostic agents for tumor-specific imaging and targeted chemotherapy
    Zhang, Renshuai
    Hao, Li
    Chen, Pengwei
    Zhang, Gang
    Liu, Ning
    BIOORGANIC CHEMISTRY, 2023, 137
123