RHD antigen density and agglutination in RHD variant red cells

被引：6

作者：

Flegel, WA ^{[1
]}

Wagner, FF ^{[1
]}

机构：

[1] UNIV ULM,ABT TRANSFUS MED,ULM,GERMANY

来源：

TRANSFUSION CLINIQUE ET BIOLOGIQUE | 1996年 / 3卷 / 06期

关键词：

antigen/epitope density; D categories; flow cytometry; RHD protein variants; rhesus blood group; serology;

D O I：

10.1016/S1246-7820(96)80049-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

For the Rhesus categories D-IV, D-VI, and D-VII, agglutination was compared to the number of RHD antigens per cell. We detected 3,100 to 15,400 antigens/cell on D-VI. We report examples of anti-D reactivity showing lack of specificity and pointing to the known serologic split in D-IV and D-VI. Such a split was not found in D-VII Other examples were explained by lack of sensitivity. These results emphazised the need to consider RHD antigen densities, before a serologic split in RHD variant cells is postulated. In this context, flow cytometry may be superior to agglutination titers to determine antigen densities.

引用

页码：385 / 386

页数：2