Antibiotic Activity of Wickerhamomyces anomalus Mycocins on Multidrug-Resistant Acinetobacter baumannii

被引：9

作者：

Junges, Daniele S. B. ^{[1
]}

Delabeneta, Mateus F. ^{[1
]}

Rosseto, Lana Rubia B. ^{[1
]}

Nascimento, Bruna L. ^{[1
]}

Paris, Ana Paula ^{[1
]}

Persel, Cristiane ^{[1
]}

Loth, Eduardo A. ^{[1
]}

Simao, Rita C. G. ^{[2
]}

Menolli, Rafael A. ^{[2
]}

Paula, Claudete R. ^{[3
]}

Gandra, Rinaldo F. ^{[1
]}

机构：

[1] Western Parana State Univ, Western Parana Univ Hosp, BR-85806470 Cascavel, Parana, Brazil

[2] Western Parana State Univ, Ctr Med & Pharmaceut Sci, BR-85819110 Cascavel, Parana, Brazil

[3] Univ Sao Paulo, Fac Odontol, BR-05508000 Butanta, SP, Brazil

来源：

MICROBIAL ECOLOGY | 2020年 / 80卷 / 02期

关键词：

Mycocins; Killer yeasts; Antibiotics; Wickerhamomyces anomalus; Acinetobacter baumannii; Multidrug resistance; PICHIA-ANOMALA; YEAST; PURIFICATION; INFECTIONS; EMERGENCE;

D O I：

10.1007/s00248-020-01495-9

中图分类号：

Q14 [生态学（生物生态学）];

学科分类号：

071012 ; 0713 ;

摘要：

To evaluate the susceptibility of multidrug-resistant Acinetobacter baumannii to mycocins produced by Wickerhamomyces anomalus and to verify the cytotoxicity of these compounds. Three culture supernatants of W. anomalus (WA40, WA45, and WA92), containing mycocins (WA40M1, WA45M2, and WA92M3), were tested on A. baumannii using broth microdilution methods, solid medium tests, and cytotoxicity tests in human erythrocytes and in Artemia saline Leach. W. anomalus was able to produce high antimicrobial mycocins, as even at high dilutions, they inhibited A. baumannii. In a solid medium, it was possible to observe the inhibition of A. baumannii, caused by the diffusion of mycocins between agar. Finally, the three supernatants were not cytotoxic when tested on human erythrocytes and Artemia salina. According to the evidence in this study, the mycocins of W. anomalus have been effective and could be used in the development of new antimicrobial substances.

引用

页码：278 / 285

页数：8

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