Comparison of a new metamizole formulation and carprofen for extended post-operative analgesia in dogs undergoing ovariohysterectomy

被引:16
作者
Guerrero, K. S. Kalchofner [1 ,2 ]
Schwarz, A. [1 ]
Wuhrmann, R. [1 ]
Feldmann, S. [3 ]
Hartnack, S. [4 ]
Bettschart-Wolfensberger, R. [1 ]
机构
[1] Univ Zurich, Vetsuisse Fac, Equine Dept, Sect Anaesthesiol, Zurich, Switzerland
[2] St Georges Univ, SVM, Small Anim Med & Surg Acad Program, True Blue, Grenada
[3] Univ Zurich, Vetsuisse Fac, Clin Reprod Med, Sect Small Anim Reprod, Zurich, Switzerland
[4] Univ Zurich, Vetsuisse Fac, Epidemiol Sect, Zurich, Switzerland
关键词
Carprofen; Dog; Metamizole; Ovariohysterectomy; Pain; ANTIINFLAMMATORY DRUGS; PAIN THERAPY; DIPYRONE; MELOXICAM; MORPHINE; ACETAMINOPHEN; ANESTHESIA; KETOPROFEN; PROPOFOL; NAUSEA;
D O I
10.1016/j.tvjl.2015.01.028
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
A newly developed slow-release tablet formulation of metamizole was compared with carprofen for postoperative analgesia in dogs undergoing ovariohysterectomy. Twenty-three dogs were randomly assigned to one of two groups, and administered 50 mg/kg metamizole PO (Group M) or 4 mg/kg carprofen PO (Group C) 1 h before anaesthetic induction and 24 and 48 h later. Anaesthesia was induced with propofol and maintained with isoflurane and fentanyl, after premedication with 0.005 mg/kg medetomidine and 0.3 mg/kg methadone IM. A blinded observer assessed post-operative sedation, and analgesia using a visual analogue scale, a dynamic interactive visual analogue scale, the Glasgow composite pain scale (GCPS), and a mechanical nociceptive threshold device (T = 0.5, 1, 2, 4, 8, 12, 18, 21, 24, 36, 45, 60 and 70 h after surgery). Rescue methadone was administered if the GCPS was >6/24 in ambulatory dogs, or >5/20 in non-ambulatory dogs. Plasma concentrations of test drugs were quantified. The dose range for metamizole was 39-.56 mg/kg. At T = 0.5 h sedation scores were significantly higher in Group C and GCPS scores were significantly higher in Group M. Three dogs required rescue methadone (Group M, n = 1; Group C, n = 2). Vomiting occurred post-operatively in 45% of dogs in Group M. Carprofen and metamizole were both well absorbed; peak concentrations occurred within 4-24 h, and 4-16 h for carprofen and metamizole, respectively. Both drugs provided adequate analgesia of similar duration. No side effects were observed with carprofen while vomiting was frequent following administration of metamizole. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码:99 / 104
页数:6
相关论文
共 48 条
[1]   Evidence for a peripheral mechanism of action for the potentiation of the antinociceptive effect of morphine by dipyrone [J].
Aguirre-Bañuelos, P ;
Granados-Soto, V .
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 1999, 42 (02) :79-85
[2]   Challenges of pain assessment in domestic animals [J].
Anil, SS ;
Anil, L ;
Deen, J .
JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 2002, 220 (03) :313-319
[3]   Owner compliance with short term antimicrobial medication in dogs [J].
Barter, LS ;
Watson, ADJ ;
Maddison, JE .
AUSTRALIAN VETERINARY JOURNAL, 1996, 74 (04) :277-280
[4]  
Brack A., 2008, ANAESTHESIOLOGIE, P99
[5]  
Camu Frederic, 2002, Best Pract Res Clin Anaesthesiol, V16, P475, DOI 10.1053/bean.2002.0262
[6]   COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression [J].
Chandrasekharan, NV ;
Dai, H ;
Roos, KLT ;
Evanson, NK ;
Tomsik, J ;
Elton, TS ;
Simmons, DL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (21) :13926-13931
[7]  
CHRIST O, 1973, ARZNEIMITTEL-FORSCH, V23, P1760
[8]  
Conzemius MG, 1997, J AM VET MED ASSOC, V210, P1619
[9]   Nonsteroidal antiinflammatory drugs: A review [J].
Curry, Stephen L. ;
Cogar, Steven M. ;
Cook, James L. .
JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 2005, 41 (05) :298-309
[10]   Postoperative nausea and vomiting in children and adolescents undergoing radiofrequency catheter ablation: A randomized comparison of propofol and isoflurane-based anesthetics [J].
Erb, TO ;
Hall, JM ;
Ing, RJ ;
Kanter, RJ ;
Kern, FH ;
Schulman, SR ;
Gan, TJ .
ANESTHESIA AND ANALGESIA, 2002, 95 (06) :1577-1581