Stepwise combinatorial evolution of Akt bisubstrate inhibitors

被引：22
作者：
Lee, Jung Hwan [1 ]
Kumar, Sanjai [1 ]
Lawrence, David S. [1 ]
机构：
[1] Yeshiva Univ Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA
来源：
CHEMBIOCHEM | 2008年 / 9卷 / 04期
关键词：
bisubstrate inhibitor; combinatorial chemistry; phosphorylation; protein kinase; signal transduction;
D O I：
10.1002/cbic.200700583
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
[No abstract available]
引用
收藏
页码：507 / 509
页数：3
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共 14 条
  • [11] Designing bisubstrate analog inhibitors for protein kinases
    Parang, K
    Cole, PA
    [J]. PHARMACOLOGY & THERAPEUTICS, 2002, 93 (2-3) : 145 - 157
  • [12] Increasing the kinase specificity of K252a by protein surface recognition
    Schneider, TL
    Mathew, RS
    Rice, KP
    Tamaki, K
    Wood, JL
    Schepartz, A
    [J]. ORGANIC LETTERS, 2005, 7 (09) : 1695 - 1698
  • [13] Synthesis and SAR of indazole-pyridine based protein kinase B/Akt inhibitors
    Woods, Keith W.
    Fischer, John P.
    Claiborne, Akiyo
    Li, Tongmei
    Thomas, Sheela A.
    Zhu, Gui-Dong
    Diebold, Robert B.
    Liu, Xuesong
    Shi, Yan
    Klinghofer, Vered
    Han, Edward K.
    Guan, Ran
    Magnone, Shayna R.
    Johnson, Eric F.
    Bouska, Jennifer J.
    Olson, Amanda M.
    de Jong, Ron
    Oltersdorf, Tilman
    Luo, Yan
    Rosenberg, Saul H.
    Giranda, Vincent L.
    Li, Qun
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (20) : 6832 - 6846
  • [14] Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP
    Yang, J
    Cron, P
    Good, VM
    Thompson, V
    Hemmings, BA
    Barford, D
    [J]. NATURE STRUCTURAL BIOLOGY, 2002, 9 (12) : 940 - 944
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