Stepwise combinatorial evolution of Akt bisubstrate inhibitors

[1] Chemical approaches to reversible protein phosphorylation [J]. ACCOUNTS OF CHEMICAL RESEARCH, 2003, 36 (06) : 444 - 452

[2] Conjugation of adenosine and hexa-(D-arginine) leads to a nanomolar bisubstrate-analog inhibitor of basophilic protein kinases [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (24) : 7150 - 7159

[3] Structure, regulation and function of PKB/AKT - a major therapeutic target [J]. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2004, 1697 (1-2): : 3 - 16

[4] Bisubstrate analog probes for the insulin receptor protein tyrosine kinase: Molecular yardsticks for analyzing catalytic mechanism and inhibitor design [J]. BIOORGANIC CHEMISTRY, 2005, 33 (04) : 285 - 297

[5] Acquisition of Fyn-selective SH3 domain ligands via a combinatorial library strategy [J]. CHEMISTRY & BIOLOGY, 2005, 12 (08): : 905 - 912

[6] A novel substrate mimetic inhibitor of PKB/Akt inhibits prostate cancer tumor growth in mice by blocking the PKB pathway [J]. BIOCHEMISTRY, 2007, 46 (16) : 4716 - 4724

[7] LIVNAH N, 2003, Patent No. 03010281

[8] Pseudosubstrate peptides inhibit Akt and induce cell growth inhibition [J]. BIOCHEMISTRY, 2004, 43 (05) : 1254 - 1263

[9] The protein kinase B/Akt signalling pathway in human malignancy [J]. CELLULAR SIGNALLING, 2002, 14 (05) : 381 - 395

[10] Peptide and protein library screening defines optimal substrate motifs for AKT/PKB [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (46) : 36108 - 36115

[1] Chemical approaches to reversible protein phosphorylation [J]. ACCOUNTS OF CHEMICAL RESEARCH, 2003, 36 (06) : 444 - 452

[2] Conjugation of adenosine and hexa-(D-arginine) leads to a nanomolar bisubstrate-analog inhibitor of basophilic protein kinases [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (24) : 7150 - 7159

[3] Structure, regulation and function of PKB/AKT - a major therapeutic target [J]. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2004, 1697 (1-2): : 3 - 16

[4] Bisubstrate analog probes for the insulin receptor protein tyrosine kinase: Molecular yardsticks for analyzing catalytic mechanism and inhibitor design [J]. BIOORGANIC CHEMISTRY, 2005, 33 (04) : 285 - 297

[5] Acquisition of Fyn-selective SH3 domain ligands via a combinatorial library strategy [J]. CHEMISTRY & BIOLOGY, 2005, 12 (08): : 905 - 912

[6] A novel substrate mimetic inhibitor of PKB/Akt inhibits prostate cancer tumor growth in mice by blocking the PKB pathway [J]. BIOCHEMISTRY, 2007, 46 (16) : 4716 - 4724

[7] LIVNAH N, 2003, Patent No. 03010281

[8] Pseudosubstrate peptides inhibit Akt and induce cell growth inhibition [J]. BIOCHEMISTRY, 2004, 43 (05) : 1254 - 1263

[9] The protein kinase B/Akt signalling pathway in human malignancy [J]. CELLULAR SIGNALLING, 2002, 14 (05) : 381 - 395

[10] Peptide and protein library screening defines optimal substrate motifs for AKT/PKB [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (46) : 36108 - 36115