In Phantom Validation of Time-Domain Near-Infrared Optical Tomography Pioneer for Imaging Brain Hypoxia and Hemorrhage

被引：2
|
作者：
Jiang, J. [1 ,2 ]
Lindner, S. [1 ,2 ,3 ]
Di Costanzo-Mata, A. [1 ,2 ]
Zhang, C. [4 ]
Charbon, E. [3 ,4 ]
Wolf, M. [1 ,2 ]
Kalyanov, A. [1 ,2 ]
机构：
[1] Univ Zurich, Dept Neonatol, Biomed Opt Res Lab BORL, Zurich, Switzerland
[2] Univ Hosp Zurich, Zurich, Switzerland
[3] EPFL Lausanne, Adv Quantum Architecture AQUA Lab, Sch Engn, Lausanne, Switzerland
[4] Delft Univ Technol, Appl Quantum Architectures, Delft, Netherlands
来源：
OXYGEN TRANSPORT TO TISSUE XLII | 2021年 / 1269卷
基金：
瑞士国家科学基金会;
关键词：
Time-domain near-infrared optical tomography (TD NITOR); Diffuse optical tomography; Tissue optical properties reconstruction; Tissue oxygenation; Preterm brain imaging; RECONSTRUCTION; PRETERM;
D O I：
10.1007/978-3-030-48238-1_54
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The neonatal brain is a vulnerable organ, and lesions due to hemorrhage and/or ischemia occur frequently in preterm neonates. Even though neuroprotective therapies exist, there is no tool available to detect the ischemic lesions. To address this problem, we have recently designed and built the new time-domain near-infrared optical tomography (TD NIROT) system - Pioneer. Here we present the results of a phantom study of the system performance. We used silicone phantoms to mimic risky situations for brain lesions: hemorrhage and hypoxia. Employing Pioneer, we were able to reconstruct accurately both position and optical properties of these inhomogeneities.
引用
收藏
页码：341 / 346
页数：6
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