Nanoparticles for Targeted Brain Drug Delivery: What Do We Know?

被引：144

作者：

Pinheiro, Ruben G. R. ^{[1
]}

Coutinho, Ana Joyce ^{[1
]}

Pinheiro, Marina ^{[1
]}

Neves, Ana Rute ^{[1
,2
]}

机构：

[1] Univ Porto, LAQV, REQUIMTE, Dept Ciencias Quim,Fac Farm, Rua Jorge Viterbo Ferreira 228, P-4050313 Porto, Portugal

[2] Univ Madeira, CQM Ctr Quim Madeira, Campus Penteada, P-9020105 Funchal, Portugal

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 21期

关键词：

Alzheimer's disease; drug delivery; drug targeting; neurodegenerative diseases; Parkinson's disease; SOLID LIPID NANOPARTICLES; PEG-PLA NANOPARTICLES; NICOTINIC ACETYLCHOLINE-RECEPTORS; IIB-IIIA COMPLEX; PLGA NANOPARTICLES; IN-VITRO; LOADED NANOPARTICLES; GLUCOSE TRANSPORTERS; TRANSFERRIN-RECEPTOR; TUMOR VASCULATURE;

D O I：

10.3390/ijms222111654

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The blood-brain barrier (BBB) is a barrier that separates the blood from the brain tissue and possesses unique characteristics that make the delivery of drugs to the brain a great challenge. To achieve this purpose, it is necessary to design strategies to allow BBB passage, in order to reach the brain and target the desired anatomic region. The use of nanomedicine has great potential to overcome this problem, since one can modify nanoparticles with strategic molecules that can interact with the BBB and induce uptake through the brain endothelial cells and consequently reach the brain tissue. This review addresses the potential of nanomedicines to treat neurological diseases by using nanoparticles specially developed to cross the BBB.

引用

页数：22

共 151 条

[1] Astrocyte-endothelial interactions at the blood-brain barrier [J].