Microbial production of bulk chemicals: development of anaerobic processes

被引:78
作者
Weusthuis, Ruud A. [1 ]
Lamot, Ischa
van der Oost, John [1 ]
Sanders, Johan P. M.
机构
[1] Wageningen Univ, Microbiol Lab, Wageningen, Netherlands
关键词
SACCHAROMYCES-CEREVISIAE; ESCHERICHIA-COLI; GLYCEROL PRODUCTION; FERMENTATION; ACID; TRANSHYDROGENASE; REGENERATION; METABOLISM; STRAINS; CELLS;
D O I
10.1016/j.tibtech.2010.12.007
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Innovative fermentation processes are necessary for the cost-effective production of bulk chemicals from renewable resources. Current microbial processes are either anaerobic processes, with high yield and productivity, or less-efficient aerobic processes. Oxygen utilization plays an important role in energy generation and redox metabolism that is necessary for product formation. The aerobic productivity, however, is relatively low because of rate-limiting volumetric oxygen transfer; whereas the product yield in the presence of oxygen is generally low because part of the substrate is completely oxidized to CO2. Hence, new microbial conversion processes for the production of bulk chemicals should be anaerobic. In this opinion article, we describe different scenarios for the development of highly efficient microbial conversion processes for the anaerobic production of bulk chemicals.
引用
收藏
页码:153 / 158
页数:6
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