Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains

被引：158
作者：
Deidda, D
Lampis, G
Fioravanti, R
Biava, M
Porretta, GC
Zanetti, S
Pompei, R
机构：
[1] Univ Cagliari, Cattedra Microbiol Applicata, Dipartimento Sci Med, I-09124 Cagliari, Italy
[2] Univ Rome La Sapienza, Dipartimento Studi Chim TSBA, Rome, Italy
[3] Univ Sassari, Ist Microbiol, I-07100 Sassari, Italy
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 11期
关键词：
D O I：
10.1128/AAC.42.11.3035
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The pyrrole derivative BM212 [1,5-diaryl-2-methyl-3-(4-methylpiperazin-1-yl) methyl-pyrrole] was shown to possess strong inhibitory activity against both Mycobacterium tuberculosis and some nontuberculosis mycobacteria. BM212 was inhibitory to drug-resistant mycobacteria and also exerted bactericidal activity against intracellular bacilli residing in the U937 human histiocytic lymphoma cell line.
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页码：3035 / 3037
页数：3
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