DNA replication: Building the perfect switch

被引：81

作者：

Diffley, JFX ^{[1
]}

机构：

[1] Imperial Canc Res Fund, Clare Hall Labs, S Mimms EN6 3LD, Herts, England

来源：

CURRENT BIOLOGY | 2001年 / 11卷 / 09期

关键词：

D O I：

10.1016/S0960-9822(01)00196-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

a sophisticated molecular switch ensures that replication origins are activated just once in each cell cycle. Recent work reveals how the proteolysis of a key replication inhibitor, geminin, by the anaphase promoting complex/cyclosome is an important component of this switch.

引用

页码：R367 / R370

页数：4

共 30 条

[11] Fission yeast WD-repeat protein Pop1 regulates genome ploidy through ubiquitin-proteasome-mediated degradation of the CDK inhibitor Rum1 and the S-phase initiator Cdc18 [J].

Kominami, K ;

Toda, T .

GENES & DEVELOPMENT, 1997, 11 (12) :1548-1560

[12] G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus [J].

Labib, K ;

Diffley, JFX ;

Kearsey, SE .

NATURE CELL BIOLOGY, 1999, 1 (07) :415-422

[13] Is the MCM2-7 complex the eukaryotic DNA replication fork helicase? [J].

Labib, K ;

Diffley, JF .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2001, 11 (01) :64-70

[14] XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis [J].

Maiorano, D ;

Moreau, J ;

Méchali, M .

NATURE, 2000, 404 (6778) :622-625

[15] Geminin, an inhibitor of DNA replication, is degraded during mitosis [J].

McGarry, TJ ;

Kirschner, MW .

CELL, 1998, 93 (06) :1043-1053

[16] Chromatin association of human origin recognition complex, Cdc6, and minichromosome maintenance proteins during the cell cycle:: Assembly of prereplication complexes in late mitosis [J].

Méndez, J ;

Stillman, B .

MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (22) :8602-8612

[17] Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7 [J].

Nguyen, VQ ;

Co, C ;

Irie, K ;

Li, JJ .

CURRENT BIOLOGY, 2000, 10 (04) :195-205

[18] The Cdt1 protein is required to license DNA for replication in fission yeast [J].

Nishitani, H ;

Lygerou, Z ;

Nishimoto, T ;

Nurse, P .

NATURE, 2000, 404 (6778) :625-+

[19] CDK inactivation is the only essential function of the APC/C and the mitotic exit network proteins for origin resetting during mitosis [J].

Noton, E ;

Diffley, JFX .

MOLECULAR CELL, 2000, 5 (01) :85-95

[20]

Oshiro G, 1999, MOL CELL BIOL, V19, P4888

← 1 2 3 →