DNA replication: Building the perfect switch

被引：81

作者：

Diffley, JFX ^{[1
]}

机构：

[1] Imperial Canc Res Fund, Clare Hall Labs, S Mimms EN6 3LD, Herts, England

来源：

CURRENT BIOLOGY | 2001年 / 11卷 / 09期

关键词：

D O I：

10.1016/S0960-9822(01)00196-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

a sophisticated molecular switch ensures that replication origins are activated just once in each cell cycle. Recent work reveals how the proteolysis of a key replication inhibitor, geminin, by the anaphase promoting complex/cyclosome is an important component of this switch.

引用

页码：R367 / R370

页数：4

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