Orchestration of membrane receptor signaling by membrane lipids

被引：22

作者：

Arish, Mohd ^{[1
]}

Husein, Atahar ^{[1
]}

Kashif, Mohammad ^{[1
]}

Sandhu, Padmani ^{[2
]}

Hasnain, Seyed E. ^{[3
]}

Akhter, Yusuf ^{[2
]}

Rub, Abdur ^{[1
]}

机构：

[1] Jamia Millia Islamia, Dept Biotechnol, Infect & Immun Lab, New Delhi 110025, India

[2] Cent Univ Himachal Pradesh, Sch Life Sci, Distt Kangra 176215, Hp, India

[3] Indian Inst Technol, Kusuma Sch Biol Sci, New Delhi 110016, India

来源：

BIOCHIMIE | 2015年 / 113卷

关键词：

Membrane; Lipid; Receptor; Membrane properties; Signaling; Host-pathogen; GROWTH-FACTOR RECEPTOR; NICOTINIC ACETYLCHOLINE-RECEPTOR; PROTEIN-COUPLED RECEPTORS; MODULATES LIGAND-BINDING; OPIOID RECEPTOR; BIOPHYSICAL PROPERTIES; EGF RECEPTOR; CHOLESTEROL DEPLETION; PHOSPHATIDIC-ACID; ARACHIDONIC-ACID;

D O I：

10.1016/j.biochi.2015.04.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Receptors on cell membrane bind to their respective ligands and transduce intracellular signals resulting in variety of effector functions. Membrane lipid composition determines the receptor signaling behavior, as the receptors assume different conformation to suit the biochemical milieu in its immediate vicinity in the membrane. Accordingly, these accommodate different signaling intermediates that dictate the course of intracellular signaling and the resulting effectors functions. In this review we provide an overview of how membrane lipids modulate membrane-properties, membrane-receptor functions and their significance in the host pathogen interaction. (C) 2015 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.

引用

页码：111 / 124

页数：14