Natural killer cells in hepatocellular carcinoma: current status and perspectives for future immunotherapeutic approaches

被引:22
|
作者
Yu, Min [1 ]
Li, Zonghai [1 ]
机构
[1] Shanghai Jiao Tong Univ, Sch Med, State Key Lab Oncogenes & Related Genes, Shanghai Canc Inst,Renji Hosp, Shanghai 200032, Peoples R China
关键词
natural killer cell; hepatocellular carcinoma; immunotherapy; IN-VIVO EXPANSION; NK CELLS; T-CELLS; RADIOFREQUENCY ABLATION; TUMOR MICROENVIRONMENT; LIGAND INCOMPATIBILITY; CANCER-IMMUNOTHERAPY; LIVER; ACTIVATION; RECEPTOR;
D O I
10.1007/s11684-017-0546-3
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Hepatocellular carcinoma (HCC) is currently the fifth most common malignancy and the third leading cause of cancer-related mortalities worldwide. In the last few years, treatments for HCC have significantly improved from a mere surgical resection to a series of minimally invasive therapies and targeted drugs. However, recurrence frequently occurs even upon curative therapeutics, and drug therapies generally produce disappointing results, with the overall prognosis dismal. This challenging clinical scenario warrants new effective and life-prolonging strategies for patients with HCC. Compelling evidence suggests that NK cells play a critical role in the immune function of the liver and in the immune defenses against HCC, indicating that HCC might be an ideal target for NK cell-based immunotherapies. To obtain comprehensive insights into the putative influence of NK cells on HCC, this paper summarizes current knowledge on NK cells in HCC and discusses the usefulness and prospects of NK cell-based immunotherapies. Critical issues that require consideration for the successful clinical translation of NK cell-based therapies are also addressed. If appropriately used and further optimized, NK cell-based therapies could dominate important roles in the future immunotherapeutic market of HCC.
引用
收藏
页码:509 / 521
页数:13
相关论文
共 50 条
  • [21] Sorafenib in advanced hepatocellular carcinoma: current status and future perspectives
    Hsu, Chih-Hung
    Shen, Ying-Chun
    Shao, Yu-Yun
    Hsu, Chiun
    Cheng, Ann-Lii
    JOURNAL OF HEPATOCELLULAR CARCINOMA, 2014, 1 : 85 - 99
  • [22] Systemic therapy of hepatocellular carcinoma: Current status and future perspectives
    Germano, Domenico
    Daniele, Bruno
    WORLD JOURNAL OF GASTROENTEROLOGY, 2014, 20 (12) : 3087 - 3099
  • [23] Personalized treatment for hepatocellular carcinoma: Current status and future perspectives
    Chan, Stephen L.
    Wong, Nathalie
    Lam, W. K. Jacky
    Kuang, Ming
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2022, 37 (07) : 1197 - 1206
  • [24] Immunotherapeutic approaches for hepatocellular carcinoma
    Longo, Vito
    Gnoni, Antonio
    Gardini, Andrea Casadei
    Pisconti, Salvatore
    Licchetta, Antonella
    Scartozzi, Mario
    Memeo, Riccardo
    Palmieri, Vincenzo Ostilio
    Aprile, Giuseppe
    Santini, Daniele
    Nardulli, Patrizia
    Silvestris, Nicola
    Brunetti, Oronzo
    ONCOTARGET, 2017, 8 (20) : 33897 - 33910
  • [25] Molecular Targeted Agents for Hepatocellular Carcinoma: Current Status and Future Perspectives
    Kudo, M.
    LIVER CANCER, 2017, 6 (02) : 101 - 112
  • [26] Local ablation therapy for hepatocellular carcinoma: current status and future perspectives
    Kudo, M
    JOURNAL OF GASTROENTEROLOGY, 2004, 39 (03) : 205 - 214
  • [27] Local ablation therapy for hepatocellular carcinoma: current status and future perspectives
    Masatoshi Kudo
    Journal of Gastroenterology, 2004, 39 : 205 - 214
  • [28] Immunotherapeutic approaches in Hepatocellular carcinoma: Building blocks of hope in near future
    Minaei, Neda
    Ramezankhani, Roya
    Tamimi, Atena
    Piryaei, Abbas
    Zarrabi, Ali
    Aref, Amir Reza
    Mostafavi, Ebrahim
    Vosough, Massoud
    EUROPEAN JOURNAL OF CELL BIOLOGY, 2023, 102 (01)
  • [29] Current and Future States of Natural Killer Cell-Based Immunotherapy in Hepatocellular Carcinoma
    Nguyen, Tu
    Chen, Po -Chun
    Pham, Janet
    Kaur, Kawaljit
    Raman, Steven S.
    Jewett, Anahid
    Chiang, Jason
    CRITICAL REVIEWS IN IMMUNOLOGY, 2024, 44 (05)
  • [30] Immunotherapeutic Approaches for Treating Hepatocellular Carcinoma
    Shen, Wanying
    Chen, Yujie
    Lei, Pan
    Sheldon, Marisela
    Sun, Yutong
    Yao, Fan
    Ma, Li
    CANCERS, 2022, 14 (20)