P-GLYCOPROTEIN AND MULTIDRUG RESISTANCE: STRUCTURE-ACTIVITY RELATIONSHIPS OF MODULATORS

被引：17
|
作者：
Huber, Paula C. [1 ]
Maruiama, Cintia H. [1 ]
Almeida, Wanda P. [1 ]
机构：
[1] Univ Estadual Campinas, Inst Quim, Dept Quim Organ, BR-13084971 Campinas, SP, Brazil
来源：
QUIMICA NOVA | 2010年 / 33卷 / 10期
关键词：
P-glycoprotein; multidrug resistance; modulators; DRUG-RESISTANCE; ABC TRANSPORTER; CELLS; INHIBITORS; BINDING; MODEL; MDR; COMBINATION; MECHANISMS; TARIQUIDAR;
D O I：
10.1590/S0100-40422010001000027
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
P-GLYCOPROTEIN AND MULTIDRUG RESISTANCE: STRUCTURE-ACTIVITY RELATIONSHIPS OF MODULATORS. Multidrug resistance, MDR is a major obstacle for cancer chemotherapy. MDR can be reversed by drugs that vary in their chemical structure and main biological activity. Many efforts have been done to overcome MDR based on studies of structure-activity relationships and in this review we summarize some aspects of MDR mediated by P-glycoprotein (P-gp), as the most experimentally and clinically tested form of drug resistance. The most significant MDR mechanisms revealed until now are shortly discussed. Physicochemical and structural properties of MDR modulators, measures of the MDR reversal, and QSAR studies are included.
引用
收藏
页码：2148 / 2154
页数：7
相关论文
共 50 条
  • [1] Flavonoid Dimers as Bivalent Modulators for P-Glycoprotein-Based Multidrug Resistance: Structure-Activity Relationships
    Chan, Kin-Fai
    Zhao, Yunzhe
    Chow, Toby W. S.
    Yan, Clare S. W.
    Ma, Dik Lung
    Burkett, Brendan A.
    Wong, Iris L. K.
    Chow, Larry M. C.
    Chan, Tak Hang
    CHEMMEDCHEM, 2009, 4 (04) : 594 - 614
  • [2] Reversal of multidrug resistance by derivatives of acrivastine: A study of structure-activity relationships of P-glycoprotein inhibitors in vitro and in vivo
    Christensen, JG
    Parks, LG
    McNutt, RW
    LeBlanc, GA
    ONCOLOGY REPORTS, 1997, 4 (06) : 1353 - 1360
  • [3] Structure-Activity Relationships of Tariquidar Analogs as Multidrug Resistance Modulators
    Pajeva, Ilza K.
    Wiese, Michael
    AAPS JOURNAL, 2009, 11 (03): : 435 - 444
  • [4] Structure-function relationships of multidrug resistance P-glycoprotein
    Pajeva, IK
    Globisch, C
    Wiese, M
    JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (10) : 2523 - 2533
  • [5] Progress in understanding the structure-activity relationships of P-glycoprotein
    Stouch, TR
    Gudmundsson, A
    ADVANCED DRUG DELIVERY REVIEWS, 2002, 54 (03) : 315 - 328
  • [6] Structure of the multidrug resistance P-glycoprotein
    Higgins, CF
    Callaghan, R
    Linton, KJ
    Rosenberg, MF
    Ford, RC
    SEMINARS IN CANCER BIOLOGY, 1997, 8 (03) : 135 - 142
  • [7] Structure-activity relationships of a series of tariquidar analogs as multidrug resistance modulators
    Globisch, C
    Pajeva, IK
    Wiese, M
    BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (05) : 1588 - 1598
  • [8] Jatrophanes as promising multidrug resistance modulators: Advances of structure-activity relationships
    Li, Jun
    Wang, Wen-qiong
    Tang, Shuai
    Song, Wei-bin
    Xuan, Li-jiang
    FITOTERAPIA, 2018, 127 : 138 - 145
  • [9] Structure and function of the multidrug resistance P-glycoprotein
    Higgins, CF
    TOXICOLOGY, 2002, 178 (01) : 19 - 20
  • [10] Structure and function of the multidrug resistance P-glycoprotein
    Higgins, CF
    Callaghan, R
    Linton, K
    Ford, R
    Rosenberg, M
    JOURNAL OF PHYSIOLOGY-LONDON, 2001, 535 : 2S - 2S
12345