Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms

被引：23

作者：

Babiloni, Claudio ^{[1
,2
,3
]}

Del Percio, Claudio ^{[4
]}

Lizio, Roberta ^{[1
,2
,3
]}

Noce, Giuseppe ^{[4
]}

Lopez, Susanna ^{[1
]}

Soricelli, Andrea ^{[4
,5
]}

Ferri, Raffaele ^{[6
]}

Pascarelli, Maria Teresa ^{[6
]}

Catania, Valentina ^{[6
]}

Nobili, Flavio ^{[7
,8
]}

Arnaldi, Dario ^{[7
,8
]}

Fama, Francesco ^{[7
,8
]}

Orzi, Francesco ^{[9
]}

Buttinelli, Carla ^{[9
]}

Giubilei, Franco ^{[9
]}

Bonanni, Laura ^{[10
,11
]}

Franciotti, Raffaella ^{[10
,11
]}

Onofrj, Marco ^{[10
,11
]}

Stirpe, Paola ^{[2
,3
]}

Fuhr, Peter ^{[12
]}

Gschwandtner, Ute ^{[12
]}

Ransmayr, Gerhard ^{[13
]}

Fraioli, Lucia ^{[2
,3
]}

Parnetti, Lucilla ^{[14
]}

Farotti, Lucia ^{[14
]}

Pievani, Michela ^{[15
]}

D'Antonio, Fabrizia ^{[16
]}

De Lena, Carlo ^{[16
]}

Guntekin, Bahar ^{[17
]}

Hanoglu, Lutfu ^{[18
]}

Yener, Gorsev ^{[19
,20
]}

Emek-Savas, Derya Durusu ^{[21
,22
]}

Triggiani, Antonio Ivano ^{[23
]}

Taylor, John Paul ^{[24
]}

McKeith, Ian ^{[24
]}

Stocchi, Fabrizio ^{[2
,3
]}

Vacca, Laura ^{[25
]}

Frisoni, Giovanni B. ^{[15
,26
,27
,28
]}

De Pandis, Maria Francesca ^{[2
,3
]}

机构：

[1] Univ Roma La Sapienza, Dept Physiol & Pharmacol Vittorio Erspamer, Rome, Italy

[2] IRCCS San Raffaele Pisana, Inst Res & Med Care, Rome, Italy

[3] Hosp San Raffaele Cassino, Cassino, Italy

[4] IRCCS SDN, Naples, Italy

[5] Univ Naples Parthenope, Dept Motor Sci & Healthiness, Naples, Italy

[6] Oasi Res Inst IRCCS, Troina, Italy

[7] IRCCS Osped Policlin San Martino, San Martino Buon Albergo, Italy

[8] Univ Genoa, Dipartimento Neurosci Oftalmol Genet Riabilitaz &, Genoa, Italy

[9] Univ Roma La Sapienza, Dept Neurosci Mental Hlth & Sensory Organs, Rome, Italy

[10] Univ G dAnnunzio, Dept Neurosci Imaging & Clin Sci, Chieti, Italy

[11] Univ G dAnnunzio, CESI, Chieti, Italy

[12] Univ Spital Basel, Abt Neurophysiol, Basel, Switzerland

[13] Johannes Kepler Univ Linz, Kepler Univ Hosp, Fac Med, Dept Neurol 2, Med Campus 3, Linz, Austria

[14] Univ Perugia, Sect Neurol, Lab Clin Neurochem, Ctr Memory Disturbances, Perugia, Italy

[15] IRCCS Ist Ctr San Giovanni di Dio Fatebenefratell, Lab Alzheimers Neuroimaging & Epidemiol, Brescia, Italy

[16] Sapienza Univ Rome, Dept Neurol & Psychiat, Rome, Italy

[17] Istanbul Medipol Univ, Dept Biophys, Istanbul, Turkey

[18] Univ Istanbul Medipol, Dept Neurol, Istanbul, Turkey

[19] Dokuz Eylul Univ, Med Sch, Dept Neurosci, Izmir, Turkey

[20] Dokuz Eylul Univ, Med Sch, Dept Neurol, Izmir, Turkey

[21] Dokuz Eylul Univ, Dept Psychol, Izmir, Turkey

[22] Dokuz Eylul Univ, Dept Neurosci, Izmir, Turkey

[23] Univ Foggia, Dept Clin & Expt Med, Foggia, Italy

[24] Newcastle Univ, Inst Neurosci, Newcastle, England

[25] Casa Cura Privata Policlin CCPP Milano SpA, Milan, Italy

[26] Univ Hosp, Memory Clin, Geneva, Switzerland

[27] Univ Hosp, LANVIE Lab Neuroimaging Aging, Geneva, Switzerland

[28] Univ Geneva, Geneva, Switzerland

来源：

NEUROBIOLOGY OF AGING | 2019年 / 73卷

基金：

欧盟地平线“2020”;

关键词：

Functional brain connectivity; Resting state EEG rhythms; Mild cognitive impairment due to Alzheimer's disease (ADMCI); Mild cognitive impairment due to Parkinson's disease (PDMCI); LOCAL-FIELD POTENTIALS; LEWY BODIES; SUBTHALAMIC NUCLEUS; OSCILLATORY ACTIVITY; ALZHEIMERS-DISEASE; BETA-OSCILLATIONS; CEREBRAL-CORTEX; BRAIN ACTIVITY; BASAL GANGLIA; BAND POWER;

D O I：

10.1016/j.neurobiolaging.2018.08.010

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

We hypothesized that dopamine neuromodulation might affect cortical excitability in Parkinson's disease (PD) patients set in quiet wakefulness, as revealed by resting state eyes-closed electroencephalographic (rsEEG) rhythms at alpha frequencies (8-12 Hz). Clinical and rsEEG rhythms in PD with dementia (N = 35), PD with mild cognitive impairment (N = 50), PD with normal cognition (N = 35), and normal (N = 50) older adults were available from an international archive. Cortical rsEEG sources were estimated by exact low-resolution brain electromagnetic tomography. Compared with the normal older group, the PD groups showed reduced occipital alpha sources and increased widespread delta (<4 Hz) sources. Widespread frontal and temporal alpha sources exhibited an increase in PD with dementia compared with PD with mild cognitive impairment and PD with normal cognition groups, as function of dopamine depletion severity, typically greater in the former than the latter groups. A daily dose of levodopa induced a widespread reduction in cortical delta and alpha sources in a subgroup of 13 PD patients under standard chronic dopaminergic regimen. In PD patients in quiet wakefulness, alpha cortical source activations may reflect an excitatory effect of dopamine neuromodulation. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：9 / 20

页数：12