Peeking into a secret world of pore-forming toxins: membrane binding processes studied by surface plasmon resonance

被引：16
|
作者：
Anderluh, G
Macek, P
Lakey, JH
机构：
[1] Univ Ljubljana, Biotech Fac, Dept Biol, Ljubljana 1000, Slovenia
[2] Univ Newcastle Upon Tyne, Sch Cell & Mol Biosci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
来源：
TOXICON | 2003年 / 42卷 / 03期
关键词：
pore-forming toxin; membrane binding; surface plasmon resonance; equinatoxin;
D O I：
10.1016/S0041-0101(03)00197-1
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Pore-formation in cell membranes is used by many toxins to kill cells. It is usually a process involving multiple steps that are difficult to analyse at the molecular level. The use of surface plasmon resonance (SPR) has only recently been introduced into the study of pore-forming toxins (PFF). It can give useful data mostly on the first steps of the pore-forming process; the binding to the lipid membranes. In particular, it can make unique contributions to our knowledge of ligand specificity and the kinetics of binding. This mini-review summarizes some recent SPR studies of PFT. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：225 / 228
页数：4
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