Pediatric sublingual allergen immunotherapy

被引:5
|
作者
Blaiss, Michael S. [1 ]
机构
[1] Augusta Univ, Med Coll Georgia, Dept Pediat, Augusta, GA USA
关键词
MITE-SENSITIZED CHILDREN; DOUBLE-BLIND; ATOPIC-DERMATITIS; EAACI GUIDELINES; EFFICACY; SAFETY; RHINITIS; RHINOCONJUNCTIVITIS; ASTHMA;
D O I
10.2500/aap.2022.43.210079
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Sublingual immunotherapy (SLIT) offers an important therapeutic modality in the management of children with respiratory allergies. Along with subcutaneous immunotherapy, these modalities are the only selections that have shown not merely relief of symptoms but also disease-modifying activity. SLIT can be given as either a dissolvable tablet (SLIT-T) or liquid drops (SLIT-D). In studies that examined the efficacy and safety in allergic rhinitis and asthma, SLIT-T and SLIT-D both show efficacy in reducing symptoms and the need for medication, although it seems that SLIT-T may show a better response. Almost all SLIT-D efficacy studies are with single allergens. There are virtually no data on the efficacy of mixing unrelated allergens in the same prescription. Both SLIT-T and SLIT-D treatments are safe, with the most common adverse effects being local ones, such as oral pruritus and mouth irritation, which tend to be mild and short lived. Studies that assess the role of SLIT in the prevention of new sensitizations and asthma in the pediatric population are insufficient and of mixed results; therefore, no conclusions can be made. In the treatment of other pediatric conditions, such as food allergy and atopic dermatitis, there are few studies that assessed if, and the degree of, the benefit with SLIT. In determining if SLIT should be prescribed for the pediatric patient, there is a need for shared decision-making to allow the older child and parents or caregivers to understand the pros and cons, and the costs of all the options and relate their values and preferences to the physician.
引用
收藏
页码:281 / 285
页数:5
相关论文
共 50 条
  • [21] Safety of sublingual immunotherapy in children
    Frati, Franco
    Ridolo, Erminia
    Fuiano, Nicola
    Barberi, Salvatore
    Dell'Albani, Ilaria
    Landi, Massimo
    Ricciardi, Luisa
    Scala, Guglielmo
    Incorvaia, Cristoforo
    EXPERT OPINION ON DRUG SAFETY, 2014, 13 (07) : 947 - 953
  • [22] Characteristics and management of sublingual allergen immunotherapy in children with allergic rhinitis and asthma induced by house dust mite allergens
    Trebuchon, Florence
    Lheritier-Barrand, Michele
    David, Marie
    Demoly, Pascal
    CLINICAL AND TRANSLATIONAL ALLERGY, 2014, 4
  • [23] Sublingual immunotherapy A focused allergen immunotherapy practice parameter update
    Greenhawt, Matthew
    Oppenheimer, John
    Nelson, Michael
    Nelson, Hal
    Lockey, Richard
    Lieberman, Phil
    Nowak-Wegrzyn, Anna
    Peters, Anju
    Collins, Charlotte
    Bernstein, David I.
    Blessing-Moore, Joann
    Khan, David
    Lang, David
    Nicklas, Richard A.
    Portnoy, Jay M.
    Randolph, Christopher R.
    Schuller, Diane E.
    Spector, Sheldon L.
    Tilles, Stephen A.
    Wallace, Dana
    ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2017, 118 (03) : 276 - +
  • [24] Sublingual immunotherapy for pediatric patients with mite allergies
    Kajiume, Teruyuki
    MEDICINE, 2022, 101 (04) : E28690
  • [25] Anaphylaxis to multiple pollen allergen sublingual immunotherapy
    Eifan, A. O.
    Keles, S.
    Bahceciler, N. N.
    Barlan, I. B.
    ALLERGY, 2007, 62 (05) : 567 - 568
  • [26] Sublingual immunotherapy
    Malling, HJ
    CLINICAL AND EXPERIMENTAL ALLERGY, 1996, 26 (11) : 1228 - 1231
  • [27] Sublingual immunotherapy: Allergen specific or placebo effect?
    Kette, Frank
    Smith, William
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2011, 128 (02) : 430 - 430
  • [28] Allergen Immunotherapy in Pediatric Respiratory Allergy
    Doroudchi, Ali
    Imam, Kamran
    Lloret, Maria Ines Garcia
    CURRENT TREATMENT OPTIONS IN ALLERGY, 2021, 8 (02) : 147 - 160
  • [29] Allergen immunotherapy in China
    Yang, Yaqi
    Li, Wenjing
    Zhu, Rongfei
    FRONTIERS IN ALLERGY, 2024, 4
  • [30] Safety and efficacy in children of an SQ-standardized grass allergen tablet for sublingual immunotherapy
    Bufe, Albrecht
    Eberle, Peter
    Franke-Beckmann, Eivy
    Funck, Juergen
    Kimmig, Martin
    Klimek, Ludger
    Knecht, Roland
    Stephan, Volker
    Tholstrup, Bente
    Weisshaar, Christian
    Kaiser, Friedrich
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2009, 123 (01) : 167 - 173