Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury

被引：500

作者：

Kruger, Philipp ^{[1
]}

Saffarzadeh, Mona ^{[2
]}

Weber, Alexander N. R. ^{[3
]}

Rieber, Nikolaus ^{[4
]}

Radsak, Markus ^{[5
]}

von Bernuth, Horst ^{[6
,7
]}

Benarafa, Charaf ^{[8
]}

Roos, Dirk ^{[9
]}

Skokowa, Julia ^{[10
]}

Hartl, Dominik ^{[4
]}

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

[2] Univ Med Ctr Mainz, CTH, Mainz, Germany

[3] Univ Tubingen, Dept Immunol, Inst Cell Biol, Tubingen, Germany

[4] Univ Tubingen, Dept Pediat 1, Tubingen, Germany

[5] Johannes Gutenberg Univ Mainz, Med Ctr, Dept Med 3, D-55122 Mainz, Germany

[6] Humboldt Univ, Charite Hosp, Dept Pediat Pneumol & Immunol, D-10099 Berlin, Germany

[7] Labor Berlin Charite Vivantes GmbH, Fachbereich Immunol, Berlin, Germany

[8] Univ Bern, Theodor Kocher Inst, Bern, Switzerland

[9] Univ Amsterdam, Acad Med Ctr, Sanquin Res & Landsteiner Lab, NL-1105 AZ Amsterdam, Netherlands

[10] Univ Tubingen, Dept Internal Med 2, Tubingen, Germany

来源：

PLOS PATHOGENS | 2015年 / 11卷 / 03期

关键词：

LEUKOCYTE-ADHESION-DEFICIENCY; CHRONIC GRANULOMATOUS-DISEASE; EXTRACELLULAR TRAP FORMATION; HEMATOLOGICALLY IMPORTANT MUTATIONS; PYOGENIC BACTERIAL-INFECTIONS; NADPH OXIDASE; CONGENITAL NEUTROPENIA; BONE-MARROW; G-CSF; IMMUNODEFICIENCY SYNDROME;

D O I：

10.1371/journal.ppat.1004651

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Neutrophils, the most abundant human immune cells, are rapidly recruited to sites of infection, where they fulfill their life-saving antimicrobial functions. While traditionally regarded as short-lived phagocytes, recent findings on long-term survival, neutrophil extracellular trap (NET) formation, heterogeneity and plasticity, suppressive functions, and tissue injury have expanded our understanding of their diverse role in infection and inflammation. This review summarises our current understanding of neutrophils in host-pathogen interactions and disease involvement, illustrating the versatility and plasticity of the neutrophil, moving between host defence, immune modulation, and tissue damage.

引用

页码：1 / 22

页数：23

共 210 条

[1] Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR [J].

A-Gonzalez, Noelia ;

Bensinger, Steven J. ;

Hong, Cynthia ;

Beceiro, Susana ;

Bradley, Michelle N. ;

Zelcer, Noam ;

Deniz, Jose ;

Ramirez, Cristina ;

Diaz, Mercedes ;

Gallardo, German ;

Ruiz de Galarreta, Carlos ;

Salazar, Jon ;

Lopez, Felix ;

Edwards, Peter ;

Parks, John ;

Andujar, Miguel ;

Tontonoz, Peter ;

Castrillo, Antonio .

IMMUNITY, 2009, 31 (02) :245-258

[2] Human phagocyte defect caused by a Rac2 mutation detected by means of neonatal screening for T-cell lymphopenia [J].

Accetta, Deborah ;

Syverson, Grant ;

Bonacci, Benedetta ;

Reddy, Sreelatha ;

Bengtson, Christine ;

Surfus, Jill ;

Harbeck, Ronald ;

Huttenlocher, Anna ;

Grossman, William ;

Routes, John ;

Verbsky, James .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2011, 127 (02) :535-538

[3] Myeloid-Related Protein-14 Contributes to Protective Immunity in Gram-Negative Pneumonia Derived Sepsis [J].

Achouiti, Ahmed ;

Vogl, Thomas ;

Urban, Constantin F. ;

Rohm, Marc ;

Hommes, Tijmen J. ;

van Zoelen, Marieke A. D. ;

Florquin, Sandrine ;

Roth, Johannes ;

van't Veer, Cornelis ;

de Vos, Alex F. ;

van der Poll, Tom .

PLOS PATHOGENS, 2012, 8 (10)

[4] Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation [J].

Ambruso, DR ;

Knall, C ;

Abell, AN ;

Panepinto, J ;

Kurkchubasche, A ;

Thurman, G ;

Gonzalez-Aller, C ;

Hiester, A ;

deBoer, M ;

Harbeck, RJ ;

Oyer, R ;

Johnson, GL ;

Roos, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (09) :4654-4659

[5] ABNORMALITIES OF POLYMORPHONUCLEAR LEUKOCYTE FUNCTION ASSOCIATED WITH A HERITABLE DEFICIENCY OF HIGH MOLECULAR-WEIGHT SURFACE GLYCOPROTEINS (GP138) - COMMON RELATIONSHIP TO DIMINISHED CELL ADHERENCE [J].

ANDERSON, DC ;

SCHMALSTIEG, FC ;

ARNAOUT, MA ;

KOHL, S ;

TOSI, MF ;

DANA, N ;

BUFFONE, GJ ;

HUGHES, BJ ;

BRINKLEY, BR ;

DICKEY, WD ;

ABRAMSON, JS ;

SPRINGER, T ;

BOXER, LA ;

HOLLERS, JM ;

SMITH, CW .

JOURNAL OF CLINICAL INVESTIGATION, 1984, 74 (02) :536-551

[6] Severe phenotype of chronic granulomatous disease presenting in a female with a de novo mutation in gp91-phox and a non familial, extremely skewed X chromosome inactivation [J].

Anderson-Cohen, M ;

Holland, SM ;

Kuhns, DB ;

Fleisher, TA ;

Ding, L ;

Brenner, S ;

Malech, HL ;

Roesler, J .

CLINICAL IMMUNOLOGY, 2003, 109 (03) :308-317

[7] Uric acid induces NADPH oxidase-independent neutrophil extracellular trap formation [J].

Arai, Yasuyuki ;

Nishinaka, Yoko ;

Arai, Toshiyuki ;

Morita, Makiko ;

Mizugishi, Kiyomi ;

Adachi, Souichi ;

Takaori-Kondo, Akifumi ;

Watanabe, Tomohiro ;

Yamashita, Kouhei .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2014, 443 (02) :556-561

[8] LEUKOKINETIC STUDIES .4. TOTAL BLOOD, CIRCULATING AND MARGINAL GRANULOCYTE POOLS AND GRANULOCYTE TURNOVER RATE IN NORMAL SUBJECTS [J].

ATHENS, JW ;

WINTROBE, MM ;

ASHENBRUCKER, H ;

CARTWRIGHT, GE ;

MAUER, AM ;

HAAB, OP ;

RAAB, SO .

JOURNAL OF CLINICAL INVESTIGATION, 1961, 40 (06) :989-&

[9] Microbiota-Derived Compounds Drive Steady-State Granulopoiesis via MyD88/TICAM Signaling [J].

Balmer, Maria L. ;

Schuerch, Christian M. ;

Saito, Yasuyuki ;

Geuking, Markus B. ;

Li, Hai ;

Cuenca, Miguelangel ;

Kovtonyuk, Larisa V. ;

Mccoy, Kathy D. ;

Hapfelmeier, Siegfried ;

Ochsenbein, Adrian F. ;

Manz, Markus G. ;

Sack, Emma ;

Macpherson, Andrew J. .

JOURNAL OF IMMUNOLOGY, 2014, 193 (10) :5273-5283

[10] Evaluation of role of G-CSF in the production, survival, and release of neutrophils from bone marrow into circulation [J].

Basu, S ;

Hodgson, G ;

Katz, M ;

Dunn, AR .

BLOOD, 2002, 100 (03) :854-861

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