Pulmonary delivery of liposomes co-loaded with SN38 prodrug and curcumin for the treatment of lung cancer

被引：18

作者：

Gao, Chengzhi ^{[1
]}

Zhang, Lanfang ^{[2
]}

Xu, Minhao ^{[1
]}

Luo, Yi ^{[1
]}

Wang, Ben ^{[1
]}

Kuang, Meiyan ^{[1
]}

Liu, Xingyou ^{[1
]}

Sun, Meng ^{[1
]}

Guo, Yue ^{[1
]}

Teng, Lesheng ^{[3
]}

Wang, Chenhui ^{[2
]}

Zhang, Yan ^{[2
]}

Xie, Jing ^{[1
]}

机构：

[1] Chongqing Univ Technol, Sch Pharm & Bioengn, 69 Hongguang Rd, Chongqing 400054, Peoples R China

[2] Chongqing Univ, Innovat Drug Res Ctr, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, 55 South Daxuecheng Rd, Chongqing 401331, Peoples R China

[3] Jilin Univ, Sch Life Sci, 2699 Qianjin Rd, Changchun 130012, Peoples R China

来源：

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2022年 / 179卷

关键词：

Pulmonary delivery; SN38; Curcumin; Lung cancer; MICROFLUIDIC SYNTHESIS; NANOPARTICLES; DOXORUBICIN; ACID;

D O I：

10.1016/j.ejpb.2022.08.021

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A co-delivery system of SN38 (7-ethyl-10-hydroxyl camptothecin) prodrug and CUR (curcumin) was designed for the treatment of lung cancer by pulmonary delivery. SN38 was linked to cell-penetrating peptide (CPP) TAT via a polyethylene glycol (PEG) linker to form the SN38 prodrug (TAT-PEG-SN38). Liposomes co-loaded with amphiphilic TAT-PEG-SN38 and curcumin (Lip-TAT-PEG-SN38/CUR) were successfully prepared by a micro -fluidic method for the treatment of lung cancer via pulmonary delivery. Lip-TAT-PEG-SN38/CUR showed nanometer-sized sphericity and a particle size of 171.21 nm. Besides, Lip-TAT-PEG-SN38/CUR exhibited enhanced antiproliferative effect, increased cell apoptosis induction and improved cell cycle arrest compared to the single agents in vitro. The combination induced significant tumor inhibition in a BALB/c mouse lung cancer model. These results indicated that our SN38 prodrug and curcumin co-delivery system was a promising candidate for lung cancer treatment.

引用

页码：156 / 165

页数：10

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