Heterodinuclear Pt(IV)-Ru(II) anticancer prodrugs to combat both drug resistance and tumor metastasis

被引：74
作者：
Ma, Lili [1 ]
Ma, Rong [1 ]
Wang, Zhigang [1 ]
Yiu, Shek-Man [1 ]
Zhu, Guangyu [1 ,2 ]
机构：
[1] City Univ Hong Kong, Dept Biol & Chem, 83 Tat Chee Ave, Hong Kong, Hong Kong, Peoples R China
[2] City Univ Hong Kong, Shenzhen Res Inst, Shenzhen, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 71期
基金：
中国国家自然科学基金;
关键词：
IN-VITRO; COMPLEXES; CANCER; DNA; CISPLATIN; THERAPY; AGENTS; APOPTOSIS; CELLS;
D O I：
10.1039/c6cc04354b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel approach to design bimetallic anticancer drug candidates with the capability to combat both drug resistance and tumor metastasis is reported. These water-soluble bifunctional Pt(IV)-Ru(II) heterodinuclear complexes with a unique mode of action display up to 2-orders of magnitude enhanced cytotoxicity in cisplatin-resistant cells and significantly impede cancer cell migration.
引用
收藏
页码：10735 / 10738
页数：4
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