Molecularly Imprinted Synthetic Antibodies: From Chemical Design to Biomedical Applications

被引:135
|
作者
Xu, Jingjing [1 ,2 ]
Miao, Haohan [1 ]
Wang, Jixiang [3 ]
Pan, Guoqing [1 ]
机构
[1] Jiangsu Univ, Inst Adv Mat, Sch Mat Sci & Engn, Zhenjiang 212013, Jiangsu, Peoples R China
[2] Shanghai Univ, Sino European Sch Technol, CN-200444 Shanghai, Peoples R China
[3] Abo Akad Univ, Dept Pharmaceut Sci Lab, FIN-20520 Turku, Finland
基金
中国国家自然科学基金;
关键词
antibody mimicking; biosensors; cancer therapy; medical diagnosis; molecularly imprinted polymers; synthetic antibodies; SOLID-PHASE SYNTHESIS; LINKED-IMMUNOSORBENT-ASSAY; CORE-SHELL PARTICLES; LABEL-FREE DETECTION; POLYMER NANOPARTICLES; DRUG-DELIVERY; QUANTUM DOTS; ARTIFICIAL ANTIBODIES; SELECTIVE RECOGNITION; MAGNETIC MICROSPHERES;
D O I
10.1002/smll.201906644
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Billions of dollars are invested into the monoclonal antibody market every year to meet the increasing demand in clinical diagnosis and therapy. However, natural antibodies still suffer from poor stability and high cost, as well as ethical issues in animal experiments. Thus, developing antibody substitutes or mimics is a long-term goal for scientists. The molecular imprinting technique presents one of the most promising strategies for antibody mimicking. The molecularly imprinted polymers (MIPs) are also called "molecularly imprinted synthetic antibodies" (MISAs). The breakthroughs of key technologies and innovations in chemistry and material science in the last decades have led to the rapid development of MISAs, and their molecular affinity has become comparable to that of natural antibodies. Currently, MISAs are undergoing a revolutionary transformation of their applications, from initial adsorption and separation to the rising fields of biomedicine. Herein, the fundamental chemical design of MISAs is examined, and then current progress in biomedical applications is the focus. Meanwhile, the potential of MISAs as qualified substitutes or even to transcend the performance of natural antibodies is discussed from the perspective of frontier needs in biomedicines, to facilitate the rapid development of synthetic artificial antibodies.
引用
收藏
页数:21
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