Molecularly Imprinted Synthetic Antibodies: From Chemical Design to Biomedical Applications
被引:135
|
作者:
Xu, Jingjing
论文数: 0引用数: 0
h-index: 0
机构:
Jiangsu Univ, Inst Adv Mat, Sch Mat Sci & Engn, Zhenjiang 212013, Jiangsu, Peoples R China
Shanghai Univ, Sino European Sch Technol, CN-200444 Shanghai, Peoples R ChinaJiangsu Univ, Inst Adv Mat, Sch Mat Sci & Engn, Zhenjiang 212013, Jiangsu, Peoples R China
Xu, Jingjing
[1
,2
]
Miao, Haohan
论文数: 0引用数: 0
h-index: 0
机构:
Jiangsu Univ, Inst Adv Mat, Sch Mat Sci & Engn, Zhenjiang 212013, Jiangsu, Peoples R ChinaJiangsu Univ, Inst Adv Mat, Sch Mat Sci & Engn, Zhenjiang 212013, Jiangsu, Peoples R China
Miao, Haohan
[1
]
Wang, Jixiang
论文数: 0引用数: 0
h-index: 0
机构:
Abo Akad Univ, Dept Pharmaceut Sci Lab, FIN-20520 Turku, FinlandJiangsu Univ, Inst Adv Mat, Sch Mat Sci & Engn, Zhenjiang 212013, Jiangsu, Peoples R China
Wang, Jixiang
[3
]
Pan, Guoqing
论文数: 0引用数: 0
h-index: 0
机构:
Jiangsu Univ, Inst Adv Mat, Sch Mat Sci & Engn, Zhenjiang 212013, Jiangsu, Peoples R ChinaJiangsu Univ, Inst Adv Mat, Sch Mat Sci & Engn, Zhenjiang 212013, Jiangsu, Peoples R China
Pan, Guoqing
[1
]
机构:
[1] Jiangsu Univ, Inst Adv Mat, Sch Mat Sci & Engn, Zhenjiang 212013, Jiangsu, Peoples R China
[2] Shanghai Univ, Sino European Sch Technol, CN-200444 Shanghai, Peoples R China
antibody mimicking;
biosensors;
cancer therapy;
medical diagnosis;
molecularly imprinted polymers;
synthetic antibodies;
SOLID-PHASE SYNTHESIS;
LINKED-IMMUNOSORBENT-ASSAY;
CORE-SHELL PARTICLES;
LABEL-FREE DETECTION;
POLYMER NANOPARTICLES;
DRUG-DELIVERY;
QUANTUM DOTS;
ARTIFICIAL ANTIBODIES;
SELECTIVE RECOGNITION;
MAGNETIC MICROSPHERES;
D O I:
10.1002/smll.201906644
中图分类号:
O6 [化学];
学科分类号:
0703 ;
摘要:
Billions of dollars are invested into the monoclonal antibody market every year to meet the increasing demand in clinical diagnosis and therapy. However, natural antibodies still suffer from poor stability and high cost, as well as ethical issues in animal experiments. Thus, developing antibody substitutes or mimics is a long-term goal for scientists. The molecular imprinting technique presents one of the most promising strategies for antibody mimicking. The molecularly imprinted polymers (MIPs) are also called "molecularly imprinted synthetic antibodies" (MISAs). The breakthroughs of key technologies and innovations in chemistry and material science in the last decades have led to the rapid development of MISAs, and their molecular affinity has become comparable to that of natural antibodies. Currently, MISAs are undergoing a revolutionary transformation of their applications, from initial adsorption and separation to the rising fields of biomedicine. Herein, the fundamental chemical design of MISAs is examined, and then current progress in biomedical applications is the focus. Meanwhile, the potential of MISAs as qualified substitutes or even to transcend the performance of natural antibodies is discussed from the perspective of frontier needs in biomedicines, to facilitate the rapid development of synthetic artificial antibodies.
机构:
Int Islamic Univ, Sulaiman Bin Abdullah Aba Al Khail Ctr Interdisci, Islamabad, PakistanUniv Karachi, ICCBS, HEJ Res Inst Chem, Karachi 75270, Pakistan
Mustafa, Ghulam
Bhanger, Muhammad Iqbal
论文数: 0引用数: 0
h-index: 0
机构:
Univ Karachi, ICCBS, HEJ Res Inst Chem, Karachi 75270, PakistanUniv Karachi, ICCBS, HEJ Res Inst Chem, Karachi 75270, Pakistan