The synthesis and biological activity of the 3-ferrocenylpropenamides derived from 5(4H)-oxazolones

被引：1
|
作者：
Wieczorek-Blauz, Anna [1 ]
Bzauz, Andrzej [2 ]
Rychlik, Blazej [2 ]
Plazuk, Damian [1 ]
机构：
[1] Univ Lodz, Fac Chem, Dept Organ Chem, Tamka 12, PL-91403 Lodz, Poland
[2] Univ Lodz, Fac Biol & Environm Protect, Dept Mol Biophys, Cytometry Lab, 141-143 Pomorska St, PL-90236 Lodz, Poland
来源：
JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2021年 / 953卷
关键词：
FERROCENYL; DERIVATIVES; MODE; INHIBITORS; DESIGN; ESTERS; SERIES; ALPHA; CELLS;
D O I：
10.1016/j.jorganchem.2021.122026
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
We described a synthesis of new 3-ferrocenylpropenamides prepared by oxazolone-ring opening reac-tion with various primary and secondary amines. The antiproliferative activities of the obtained com-pounds were screened on human tumor cell lines (HCT116, SW620, Colo 205, MCF-7, HepG2 and A549). We found that the newly prepared compounds showed cytotoxicity in micromolar range, with the most active piperidinyl derivative 6b with IC50 values 8.1 mu M (MCF-7), 9.6 mu M (SW620) and 13.2 mu M (Colo 205). Cell cycle analysis showed that 6b increases number of G2/M arrested cells. (c) 2021 Elsevier B.V. All rights reserved.
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页数：7
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