Mitochondrial Dysfunction and Ovarian Aging

被引：113
作者：
Kasapoglu, Isil [1 ]
Seli, Emre [1 ,2 ]
机构：
[1] Yale Sch Med, New Haven, CT 06520 USA
[2] IVIRMA New Jersey, Basking Ridge, NJ 07920 USA
来源：
ENDOCRINOLOGY | 2020年 / 161卷 / 02期
关键词：
mitochondrial dysfunction; ovarian aging; oocyte; mitochondrial DNA; DNA COPY NUMBER; LIFETIME IMAGING MICROSCOPY; UNFOLDED PROTEIN RESPONSE; IN-VITRO FERTILIZATION; FISSION FACTOR DRP1; ALPHA-LIPOIC ACID; CELLULAR SENESCENCE; OXIDATIVE STRESS; NONINVASIVE MEASUREMENT; OOCYTE QUALITY;
D O I：
10.1210/endocr/bqaa001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
As women delay childbearing because of demographic and socioeconomic trends, reproductive aging and ensuing ovarian dysfunction become increasingly more prevalent causes of infertility. Age-related decline in fertility is characterized by both quantitative and qualitative deterioration of the ovarian reserve. Importantly, disorders of aging are frequently associated with mitochondrial dysfunction, as are impaired oogenesis and embryogenesis. Ongoing research explores the role of mitochondrial dysfunction in ovarian aging, and potential ways to exploit mitochondrial mechanisms to slow down or reverse age-related changes in female gonads.
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页数：11
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