The role of TNFR2+ Tregs in COVID-19: An overview and a potential therapeutic strategy

被引：12
|
作者：
Ahmad, Suhana [1 ]
Hatmal, Ma'mon M. [2 ]
Lambuk, Lidawani [1 ]
Al-Hatamleh, Mohammad A., I [1 ]
Alshaer, Walhan [3 ]
Mohamud, Rohimah [1 ]
机构：
[1] Univ Sains Malaysia, Sch Med Sci, Dept Immunol, Kubang Kerian 16150, Kelantan, Malaysia
[2] Hashemite Univ, Fac Appl Hlth Sci, Dept Med Lab Sci, POB 330127, Zarqa 13133, Jordan
[3] Univ Jordan, Cell Therapy Ctr CTC, Amman 11942, Jordan
来源：
LIFE SCIENCES | 2021年 / 286卷
关键词：
TNF-TNFR2; SARS-CoV-2; Immunotherapy; Immune tolerance; TUMOR-NECROSIS-FACTOR; REGULATORY T-CELLS; NF-KAPPA-B; TNF-ALPHA; RECEPTOR; IMMUNE-RESPONSE; EXPRESSION; PHENOTYPE; MACROPHAGES; SUPPRESSION;
D O I：
10.1016/j.lfs.2021.120063
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
COVID-19 is a multi-faceted disease ranging from asymptomatic to severely ill condition that primarily affects the lungs and could advance to other organs as well. It's causing factor, SARS-CoV-2 is recognized to develop robust cell-mediated immunity that responsible to either control or exaggerate the infection. As an important cell subset that control immune responses and are significantly dysregulated in COVID-19, Tregs is proposed to be considered for COVID-19 management. Among its hallmark, TNFR2 is recently recognized to play important role in the function and survival of Tregs. This review gathers available TNFR2 agonists to directly target Tregs as a potential approach to overcome immune dysregulation that affect the severity in COVID-19. Furthermore, this review performs a rigid body docking of TNF-TNFR2 interaction and such interaction with TNFR2 agonist to predict the optimal targeting approach.
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页数：8
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