The role of TNFR2+ Tregs in COVID-19: An overview and a potential therapeutic strategy

被引：13

作者：

Ahmad, Suhana ^{[1
]}

Hatmal, Ma'mon M. ^{[2
]}

Lambuk, Lidawani ^{[1
]}

Al-Hatamleh, Mohammad A., I ^{[1
]}

Alshaer, Walhan ^{[3
]}

Mohamud, Rohimah ^{[1
]}

机构：

[1] Univ Sains Malaysia, Sch Med Sci, Dept Immunol, Kubang Kerian 16150, Kelantan, Malaysia

[2] Hashemite Univ, Fac Appl Hlth Sci, Dept Med Lab Sci, POB 330127, Zarqa 13133, Jordan

[3] Univ Jordan, Cell Therapy Ctr CTC, Amman 11942, Jordan

来源：

LIFE SCIENCES | 2021年 / 286卷

关键词：

TNF-TNFR2; SARS-CoV-2; Immunotherapy; Immune tolerance; TUMOR-NECROSIS-FACTOR; REGULATORY T-CELLS; NF-KAPPA-B; TNF-ALPHA; RECEPTOR; IMMUNE-RESPONSE; EXPRESSION; PHENOTYPE; MACROPHAGES; SUPPRESSION;

D O I：

10.1016/j.lfs.2021.120063

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

COVID-19 is a multi-faceted disease ranging from asymptomatic to severely ill condition that primarily affects the lungs and could advance to other organs as well. It's causing factor, SARS-CoV-2 is recognized to develop robust cell-mediated immunity that responsible to either control or exaggerate the infection. As an important cell subset that control immune responses and are significantly dysregulated in COVID-19, Tregs is proposed to be considered for COVID-19 management. Among its hallmark, TNFR2 is recently recognized to play important role in the function and survival of Tregs. This review gathers available TNFR2 agonists to directly target Tregs as a potential approach to overcome immune dysregulation that affect the severity in COVID-19. Furthermore, this review performs a rigid body docking of TNF-TNFR2 interaction and such interaction with TNFR2 agonist to predict the optimal targeting approach.

引用

页数：8

共 96 条

[1] Acquisition of regulatory function by human CD8+ T cells treated with anti-CD3 antibody requires TNF [J].

Ablamunits, Vitaly ;

Bisikirska, Brygida ;

Herold, Kevan C. .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2010, 40 (10) :2891-2901

[2] The Key Role of TNF-TNFR2 Interactions in the Modulation of Allergic Inflammation: A Review [J].

Ahmad, Suhana ;

Azid, Nor Azrini ;

Boer, Jennifer C. ;

Lim, JitKang ;

Chen, Xin ;

Plebanski, Magdalena ;

Mohamud, Rohimah .

FRONTIERS IN IMMUNOLOGY, 2018, 9

[3] Synergistic Effects of Nanomedicine Targeting TNFR2 and DNA Demethylation Inhibitor-An Opportunity for Cancer Treatment [J].

Al-Hatamleh, Mohammad A. I. ;

Syafirah, Engku Nur E. A. R. ;

Boer, Jennifer C. ;

Ferji, Khalid ;

Six, Jean-Luc ;

Chen, Xin ;

Elkord, Eyad ;

Plebanski, Magdalena ;

Mohamud, Rohimah .

CELLS, 2020, 9 (01)

[4] A Perspective Review on the Role of Nanomedicine in the Modulation of TNF-TNFR2 Axis in Breast Cancer Immunotherapy [J].

Al-Hatamleh, Mohammad A. I. ;

Ahmad, Suhana ;

Boer, Jennifer C. ;

Lim, JitKang ;

Chen, Xin ;

Plebanski, Magdalena ;

Mohamud, Rohimah .

JOURNAL OF ONCOLOGY, 2019, 2019

[5] Phenotype, localization, and mechanism of suppression of CD4+CD25+ human thymocytes [J].

Annunziato, F ;

Cosmi, L ;

Liotta, F ;

Lazzeri, E ;

Manetti, R ;

Vanini, V ;

Romagnani, P ;

Maggi, E ;

Romagnani, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (03) :379-387

[6]

Balcewicz-Sablinska MK, 1998, J IMMUNOL, V161, P2636

[7] Interleukin 10 produced by macrophages inoculated with Mycobacterium avium attenuates mycobacteria-induced apoptosis by reduction of TNF-α activity [J].

Balcewicz-Sablinska, MK ;

Gan, HX ;

Remold, HG .

JOURNAL OF INFECTIOUS DISEASES, 1999, 180 (04) :1230-1237

[8] Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19 [J].

Blanco-Melo, Daniel ;

Nilsson-Payant, Benjamin E. ;

Liu, Wen-Chun ;

Uhl, Skyler ;

Hoagland, Daisy ;

Moller, Rasmus ;

Jordan, Tristan X. ;

Oishi, Kohei ;

Panis, Maryline ;

Sachs, David ;

Wang, Taia T. ;

Schwartz, Robert E. ;

Lim, Jean K. ;

Albrecht, Randy A. ;

tenOever, Benjamin R. .

CELL, 2020, 181 (05) :1036-+

[9] The dysregulated innate immune response in severe COVID-19 pneumonia that could drive poorer outcome [J].

Blot, Mathieu ;

Bour, Jean-Baptiste ;

Quenot, Jean Pierre ;

Bourredjem, Abderrahmane ;

Nguyen, Maxime ;

Guy, Julien ;

Monier, Serge ;

Georges, Marjolaine ;

Large, Audrey ;

Dargent, Auguste ;

Guilhem, Alexandre ;

Mouries-Martin, Suzanne ;

Barben, Jeremy ;

Bouhemad, Belaid ;

Charles, Pierre-Emmanuel ;

Chavanet, Pascal ;

Binquet, Christine ;

Piroth, Lionel .

JOURNAL OF TRANSLATIONAL MEDICINE, 2020, 18 (01)

[10] The two NF-κB activation pathways and their role in innate and adaptive immunity [J].

Bonizzi, G ;

Karin, M .

TRENDS IN IMMUNOLOGY, 2004, 25 (06) :280-288

← 1 2 3 4 5 6 7 8 9 10 →