Sphingosylphosphorylcholine ameliorates experimental sj?gren?s syndrome by regulating salivary gland inflammation and hypofunction, and regulatory B cells

被引：1

作者：

Kim, Da Som ^{[1
,2
,3
]}

Na, Hyun Sik ^{[1
,2
,3
]}

Cho, Keun-Hyung ^{[1
,2
,3
]}

Lee, Kun Hee ^{[1
,2
,3
]}

Choi, JeongWon ^{[1
,2
,5
,6
]}

Kwok, Seung-Ki ^{[1
,4
,7
]}

Bae, Yoe-Sik ^{[5
,6
]}

Cho, Mi-La ^{[1
,2
,7
]}

Park, Sung-Hwan ^{[1
,4
]}

机构：

[1] Catholic Univ Korea, Catholic Res Inst Med Sci, Coll Med, Rheumatism Res Ctr, 222 Banpo Daero, Seoul 06591, South Korea

[2] Catholic Univ Korea, Catholic Res Inst Med Sci, Coll Med, Lab Translat ImmunoMed, Seoul, South Korea

[3] Catholic Univ Korea, Coll Med, Dept Biomed & Hlth Sci, Seoul 06591, South Korea

[4] Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Internal Med,Div Rheumatol, 222 Banpo Daero, Seoul 06591, South Korea

[5] Sungkyunkwan Univ, Dept Biol Sci, Suwon 16419, South Korea

[6] Sungkyunkwan Univ, SAIHST, Dept Hlth Sci & Technol, Seoul 06355, South Korea

[7] Catholic Univ Korea, Coll Med, Dept Med Life Sci, 222 Banpo Daero, Seoul 06591, South Korea

来源：

IMMUNOLOGY LETTERS | 2022年 / 248卷

关键词：

Sjö gren syndrome; Sphingosylphosphorylcholine; Regulatory B cells; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; COLLAGEN-INDUCED ARTHRITIS; SPHINGOSINE; 1-PHOSPHATE; T-CELLS; SJOGRENS-SYNDROME; SIGNALING MECHANISMS; DENDRITIC CELLS; FTY720; RECEPTORS; MIGRATION;

D O I：

10.1016/j.imlet.2022.06.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sjogren syndrome (SS) is an autoimmune disease in which immune cells infiltrate the exocrine gland. Since SS is caused by a disorder of the immune system, treatments should regulate the immune response. Sphingosylphosphorylcholine (SPC) is a sphingolipid that mediates cellular signaling. In immune cells, SPC has several immunomodulatory functions. Accordingly, this study verifies the immunomodulatory ability and therapeutic effect of SPC in SS. To understand the function of SPC in SS, we treated SPC in female NOD/ShiJcl (NOD) mice. The mice were monitored for 10 weeks, and inflammation in the salivary glands was checked. After SPC treatment, we detected the expression of regulatory B (Breg) cells in mouse splenocytes and the level of salivary secretion-related genes in human submandibular gland (HSG) cells. Salivary flow rate was maintained in the SPC-treated group compared to the vehicle-treated group, and inflammation in the salivary gland tissues was relieved by SPC. SPC treatment in mouse cells and HSG cells enhanced Breg cells and salivary secretion markers, respectively. This study revealed that SPC can be considered as a new therapeutic agent against SS.

引用

页码：62 / 69

页数：8

共 42 条

[41] Short-chain fatty acid butyrate induces IL-10-producing B cells by regulating circadian-clock-related genes to ameliorate Sjo?gren?s syndrome
Kim, Da Som
Woo, Jin Seok
Min, Hong-Ki
Choi, Jeong-Won
Moon, Jeong Hyeon
Park, Min-Jung
Kwok, Seung-Ki
Park, Sung-Hwan
Cho, Mi-La
JOURNAL OF AUTOIMMUNITY, 2021, 119
[42] Labial Gland Mesenchymal Stem Cell Derived Exosomes-Mediated miRNA-125b Attenuates Experimental Sjogren's Syndrome by Targeting PRDM1 and Suppressing Plasma Cells
Xing, Yixiao
Li, Boya
He, Jing
Hua, Hong
FRONTIERS IN IMMUNOLOGY, 2022, 13

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