Capacitative calcium entry: sensing the calcium stores

被引：145
作者：
Putney, JW [1 ]
机构：
[1] NIEHS, Lab Signal Transduct, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC 27709 USA
来源：
JOURNAL OF CELL BIOLOGY | 2005年 / 169卷 / 03期
关键词：
D O I：
10.1083/jcb.200503161
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
A long-standing mystery in the cell biology of calcium channel regulation is the nature of the signal linking intracellular calcium stores to plasma membrane capacitative calcium entry channels. An RNAi-based screen of selected Drosophila genes has revealed that a calcium-binding protein, stromal interaction molecule ( STIM), plays an essential role in the activation of these channels and may be the long sought sensor of calcium store content.
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页码：381 / 382
页数：2
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