Photoacoustic diagnosis of burns in rats: two-dimensional photoacoustic imaging of burned tissue

被引：4

作者：

Yamazaki, M ^{[1
]}

Sato, S ^{[1
]}

Saito, D ^{[1
]}

Okada, Y ^{[1
]}

Kurita, A ^{[1
]}

Kikuchi, M ^{[1
]}

Ashida, H ^{[1
]}

Obara, M ^{[1
]}

机构：

[1] Keio Univ, Dept Elect & Elect Engn, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan

来源：

BIOMEDICAL OPTOACOUSTICS IV | 2003年 / 4960卷

关键词：

photoacoustic signals; bum depth diagnosis; piezoelectric transducer; rat burn model; skin tomogram;

D O I：

10.1117/12.477638

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

We previously reported that for rat burn models, deep dermal :burns and deep burns can be well differentiated by the propagation time of the photoacoustic signals originated from the blood in the healthy skin tissue under the damaged tissue. However; the diagnosis was based on point measurement In the wound, and therefore site-dependent information on the injuries was not obtained; such information is very important for diagnosis. of extended burns. In the present study, we scanned a photoacoustic detector on the wound and constructed two-dimensional (2-D) images of the blood-originated photoacoustic signals for superficial dermal burns (SDB); deep dermal burns (DDB), deep burns (DB); and healthy skins (control) in rats. For each burn, site-dependent variation of the signal was observed; the variation probably reflects the non-uniform distribution of blood vessels in the skin tissue. In spite of the variation, clear differentiation was obtained between SDB, DDB, and DB from the images. The images were constructed. as a function of post burn time. Temporal signal variation will also be presented.

引用

页码：7 / 13

页数：7