Wave propagation in cardiac tissue and effects of intracellular calcium dynamics (computer simulation study)

被引：22
作者：
Chudin, E
Garfinkel, A
Weiss, J
Karplus, W
Kogan, B
机构：
[1] Univ Calif Los Angeles, Dept Biomath, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Dept Cardiol, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Dept Comp Sci, Los Angeles, CA 90095 USA
来源：
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY | 1998年 / 69卷 / 2-3期
关键词：
D O I：
10.1016/S0079-6107(98)00009-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Computer simulation using Luo-Rudy I1 model of ventricular myocyte showed that intracellular calcium dynamics become irregular in case of high rate stimulation. This causes the transition from stationary to nonstationary spiral wave and its breakup in 2D model of cardiac tissue. Obtained results suggest how ventricular fibrillation may occur due to the abnormalities of intracellular calcium dynamics. The short review of existing cardiac cell models with calcium dynamics is presented. (C) 1998 Elsevier Science Ltd. All rights reserved.
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页码：225 / 236
页数：12
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