ANTIMICROBIAL PEPTIDE, LL-37, AND ITS POTENTIAL AS AN ANTI-HIV AGENT

被引：8
|
作者：
Vera-Cruz, Ana [1 ,2 ]
Tanphaichitr, Nongnuj [2 ,3 ]
Angel, Jonathan B. [1 ,2 ,4 ]
机构：
[1] Univ Ottawa, Dept Biochem Microbiol & Immunol, Ottawa, ON, Canada
[2] Ottawa Hosp Res Inst, Chron Dis Program, Ottawa, ON, Canada
[3] Univ Ottawa, Dept Obstet Gynecol, Ottawa, ON, Canada
[4] Ottawa Hosp, Div Infect Dis, Ottawa, ON, Canada
来源：
CLINICAL AND INVESTIGATIVE MEDICINE | 2021年 / 44卷 / 03期
关键词：
HUMAN CATHELICIDIN LL-37; ALPHA-DEFENSINS; PREEXPOSURE PROPHYLAXIS; THETA-DEFENSINS; DRUG-DELIVERY; INFECTION; TYPE-1; CELL; PROTEIN; VAGINA;
D O I：
10.25011/cim.v44i3.36657
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Human immunodeficiency virus (HIV) continues to have a profound global health impact. New infections continue at a high rate despite the development of prophylactic therapies, prompting the need for development of novel preventative approaches. Antimicrobial peptides (AMPs), such as LL-37, display broad microbicidal properties and have potential as anti-HIV agents. LL-37 has been studied for its anti-HIV activity and the limited data available suggest it can inhibit HIV infection in primary T cells as well as exert inhibitory effects on key HIV enzymes. Its immunomodulatory properties may both enhance and inhibit HIV replication. In addition, LL-37 has both 1) the ability to kill other sexually-transmitted pathogens and 2) spermicidal activity; thus, it is a good candidate for multipurpose prevention technology. Further investigation of its anti-HIV activity is warranted.
引用
收藏
页码：E64 / E71
页数：8
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