"Let's Stay Together"; GIP and GLP-1 dual agonism in the treatment of metabolic disease

被引：6

作者：

DiMarchi, Richard D. ^{[1
,2
]}

机构：

[1] Indiana Univ, Dept Chem, Bloomington, IN 47405 USA

[2] Novo Nordisk, Bagsvaerd, Denmark

来源：

MOLECULAR METABOLISM | 2018年 / 18卷

关键词：

D O I：

10.1016/j.molmet.2018.10.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：1 / 2

页数：2

共 10 条

[1]

Campbell J, 2013, CELL METAB, V17, P1

[2] LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept [J].

Coskun, Tamer ;

Sloop, Kyle W. ;

Loghin, Corina ;

Alsina-Fernandez, Jorge ;

Urva, Shweta ;

Bokvist, Krister B. ;

Cui, Xuewei ;

Briere, Daniel A. ;

Cabrera, Over ;

Roell, William C. ;

Kuchibhotla, Uma ;

Moyers, Julie S. ;

Benson, Charles T. ;

Gimeno, Ruth E. ;

D'Alessio, David A. ;

Haupt, Axel .

MOLECULAR METABOLISM, 2018, 18 :3-14

[3] Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists Specifically Optimized for Multidose Formulations [J].

Evers, Andreas ;

Bossart, Martin ;

Pfeiffer-Marek, Stefania ;

Elvert, Ralf ;

Schreuder, Herman ;

Kurz, Michael ;

Stengelin, Siegfried ;

Lorenz, Martin ;

Herling, Andreas ;

Konkar, Anish ;

Lukasczyk, Ulrike ;

Pfenninger, Anja ;

Lorenz, Katrin ;

Haack, Torsten ;

Kadereit, Dieter ;

Wagner, Michael .

JOURNAL OF MEDICINAL CHEMISTRY, 2018, 61 (13) :5580-5593

[4] Reappraisal of GIP Pharmacology for Metabolic Diseases [J].

Finan, Brian ;

Mueller, Timo D. ;

Clemmensen, Christoffer ;

Perez-Tilve, Diego ;

DiMarchi, Richard D. ;

Tschoep, Matthias H. .

TRENDS IN MOLECULAR MEDICINE, 2016, 22 (05) :359-376

[5] A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents [J].

Finan, Brian ;

Yang, Bin ;

Ottaway, Nickki ;

Smiley, David L. ;

Ma, Tao ;

Clemmensen, Christoffer ;

Chabenne, Joe ;

Zhang, Lianshan ;

Habegger, Kirk M. ;

Fischer, Katrin ;

Campbell, Jonathan E. ;

Sandoval, Dar Leen ;

Seeley, Randy J. ;

Bleicher, Konrad ;

Uhles, Sabine ;

Riboulet, William ;

Funk, Jurgen ;

Hertel, Cornelia ;

Belli, Sara ;

Sebokova, Elena ;

Conde-Knape, Karin ;

Konkar, Anish ;

Drucker, Daniel J. ;

Gelfanov, Vasily ;

Pfluger, Paul T. ;

Muller, Timo D. ;

Perez-Tilve, Diego ;

DiMarchi, Richard D. ;

Tschop, Matthias H. .

NATURE MEDICINE, 2015, 21 (01) :27-36

[6] Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans [J].

Finan, Brian ;

Ma, Tao ;

Ottaway, Nickki ;

Mueller, Timo D. ;

Habegger, Kirk M. ;

Heppner, Kristy M. ;

Kirchner, Henriette ;

Holland, Jenna ;

Hembree, Jazzminn ;

Raver, Christine ;

Lockie, Sarah H. ;

Smiley, David L. ;

Gelfanov, Vasily ;

Yang, Bin ;

Hofmann, Susanna ;

Bruemmer, Dennis ;

Drucker, Daniel J. ;

Pfluger, Paul T. ;

Perez-Tilve, Diego ;

Gidda, Jaswant ;

Vignati, Louis ;

Zhang, Lianshan ;

Hauptman, Jonathan B. ;

Lau, Michele ;

Brecheisen, Mathieu ;

Uhles, Sabine ;

Riboulet, William ;

Hainaut, Emmanuelle ;

Sebokova, Elena ;

Conde-Knape, Karin ;

Konkar, Anish ;

DiMarchi, Richard D. ;

Tschoep, Matthias H. .

SCIENCE TRANSLATIONAL MEDICINE, 2013, 5 (209)

[7] Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial [J].

Frias, Juan Pablo ;

Nauck, Michael A. ;

Van, Joanna ;

Kutner, Mark E. ;

Cui, Xuewei ;

Benson, Charles ;

Urva, Shweta ;

Gimeno, Ruth E. ;

Milicevic, Zvonko ;

Robins, Deborah ;

Haupt, Axel .

LANCET, 2018, 392 (10160) :2180-2193

[8] The Sustained Effects of a Dual GIP/GLP-1 Receptor Agonist, NNC0090-2746, in Patients with Type 2 Diabetes [J].

Frias, Juan Pablo ;

Bastyr, Edward J., III ;

Vignati, Louis ;

Tschoep, Matthias H. ;

Schmitt, Christophe ;

Owen, Klara ;

Christensen, Rune Haubo ;

DiMarchi, Richard D. .

CELL METABOLISM, 2017, 26 (02) :343-+

[9] Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide [J].

Lau, Jesper ;

Bloch, Paw ;

Schaffer, Lauge ;

Pettersson, Ingrid ;

Spetzler, Jane ;

Kofoed, Jacob ;

Madsen, Kjeld ;

Knudsen, Lotte Bjerre ;

McGuire, James ;

Steensgaard, Dorte Bjerre ;

Strauss, Holger Martin ;

Gram, Dorte X. ;

Knudsen, Sanne Moller ;

Nielsen, Flemming Seier ;

Thygesen, Peter ;

Reedtz-Runge, Steffen ;

Kruse, Thomas .

JOURNAL OF MEDICINAL CHEMISTRY, 2015, 58 (18) :7370-7380

[10] Semaglutide versus dulaglutide once weekly in patients with type 2 diabetes (SUSTAIN 7): a randomised, open-label, phase 3b trial [J].

Pratley, Richard E. ;

Aroda, Vanita R. ;

Lingvay, Ildiko ;

Luedemann, Jorg ;

Andreassen, Camilla ;

Navarria, Andrea ;

Viljoen, Adie .

LANCET DIABETES & ENDOCRINOLOGY, 2018, 6 (04) :275-286

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