Long Non-Coding RNA: A Potential Strategy for the Diagnosis and Treatment of Colorectal Cancer

被引：13
作者：
Chen, Shanshan [1 ]
Fang, Yi [1 ,2 ]
Sun, Lingyu [1 ,2 ]
He, Ruonan [2 ]
He, Beihui [1 ]
Zhang, Shuo [1 ]
机构：
[1] Zhejiang Chinese Med Univ, Affiliated Hosp 1, Hangzhou, Peoples R China
[2] Zhejiang Chinese Med Univ, Clin Med Coll 1, Hangzhou, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2021年 / 11卷
基金：
中国国家自然科学基金;
关键词：
long non-coding RNA; colorectal cancer; drug resistance; proliferation; metastasis; occurrence; invasion; EPITHELIAL-MESENCHYMAL-TRANSITION; COLON-CANCER; STEM-CELLS; PROGNOSTIC-FACTOR; HIPPO PATHWAY; EXPRESSION; PROLIFERATION; PROMOTES; PROTEIN; TRANSCRIPTION;
D O I：
10.3389/fonc.2021.762752
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Colorectal cancer (CRC), being one of the most commonly diagnosed cancers worldwide, endangers human health. Because the pathological mechanism of CRC is not fully understood, there are many challenges in the prevention, diagnosis, and treatment of this disease. Long non-coding RNAs (lncRNAs) have recently drawn great attention for their potential roles in the different stages of CRC formation, invasion, and progression, including regulation of molecular signaling pathways, apoptosis, autophagy, angiogenesis, tumor metabolism, immunological responses, cell cycle, and epithelial-mesenchymal transition (EMT). This review aims to discuss the potential mechanisms of several oncogenic lncRNAs, as well as several suppressor lncRNAs, in CRC occurrence and development to aid in the discovery of new methods for CRC diagnosis, treatment, and prognosis assessment.</p>
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页数：13
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