共 21 条
In vitro benchtop mock circulatory loop for heart failure with preserved ejection fraction emulation
被引:10
作者:

Malone, Andrew
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Univ Med & Hlth Sci, Royal Coll Surg Ireland RCSI, Dept Anat & Regenerat Med, Tissue Engn Res Grp, Dublin, Ireland Univ Med & Hlth Sci, Royal Coll Surg Ireland RCSI, Dept Anat & Regenerat Med, Tissue Engn Res Grp, Dublin, Ireland

Gallagher, Sean
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h-index: 0
机构:
Natl Coll Art & Design, Med Device Design, Dublin, Ireland Univ Med & Hlth Sci, Royal Coll Surg Ireland RCSI, Dept Anat & Regenerat Med, Tissue Engn Res Grp, Dublin, Ireland

Saidi, Jemil
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Univ Med & Hlth Sci, Royal Coll Surg Ireland RCSI, Dept Anat & Regenerat Med, Tissue Engn Res Grp, Dublin, Ireland Univ Med & Hlth Sci, Royal Coll Surg Ireland RCSI, Dept Anat & Regenerat Med, Tissue Engn Res Grp, Dublin, Ireland

Rizq, Gina
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Univ Med & Hlth Sci, Royal Coll Surg Ireland RCSI, Dept Anat & Regenerat Med, Tissue Engn Res Grp, Dublin, Ireland
Univ Med & Hlth Sci, Royal Coll Surg Ireland RCSI, Sch Med, Dublin, Ireland Univ Med & Hlth Sci, Royal Coll Surg Ireland RCSI, Dept Anat & Regenerat Med, Tissue Engn Res Grp, Dublin, Ireland

O'Dowd, Enda
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Natl Coll Art & Design, Med Device Design, Dublin, Ireland Univ Med & Hlth Sci, Royal Coll Surg Ireland RCSI, Dept Anat & Regenerat Med, Tissue Engn Res Grp, Dublin, Ireland

Vallence, Derek
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Natl Coll Art & Design, Med Device Design, Dublin, Ireland Univ Med & Hlth Sci, Royal Coll Surg Ireland RCSI, Dept Anat & Regenerat Med, Tissue Engn Res Grp, Dublin, Ireland

Hameed, Aamir
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h-index: 0
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Univ Med & Hlth Sci, Royal Coll Surg Ireland RCSI, Dept Anat & Regenerat Med, Tissue Engn Res Grp, Dublin, Ireland
Trinity Coll Dublin, Trinity Ctr Biomed Engn, Dublin, Ireland Univ Med & Hlth Sci, Royal Coll Surg Ireland RCSI, Dept Anat & Regenerat Med, Tissue Engn Res Grp, Dublin, Ireland
机构:
[1] Univ Med & Hlth Sci, Royal Coll Surg Ireland RCSI, Dept Anat & Regenerat Med, Tissue Engn Res Grp, Dublin, Ireland
[2] Natl Coll Art & Design, Med Device Design, Dublin, Ireland
[3] Univ Med & Hlth Sci, Royal Coll Surg Ireland RCSI, Sch Med, Dublin, Ireland
[4] Trinity Coll Dublin, Trinity Ctr Biomed Engn, Dublin, Ireland
来源:
FRONTIERS IN CARDIOVASCULAR MEDICINE
|
2022年
/
9卷
关键词:
Heart Failure with preserved Ejection Fraction (HFpEF);
left atrium (LA);
left ventricle (LV);
mock circulation loop;
electro-pneumatic regulator;
PATHOPHYSIOLOGY;
HEMODYNAMICS;
D O I:
10.3389/fcvm.2022.910120
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
In this work, a novel mock circulatory loop (MCL) is presented that is capable of simulating both healthy cardiac function and Heart Failure with preserved Ejection Fraction (HFpEF). This MCL differs from others presented in the literature as it features two independently actuated heart chambers, representing the left atrium and the left ventricle. This is an important improvement over other designs as it allows for potential HFpEF treatments to be examined, not just in relation to their effect on the left ventricle but also on the left atrium. The aim of this work was to show that novel MCL designs could be developed to allow for testing of new mechanical circulatory support devices for the treatment of HFpEF. Two loop configurations are presented, one featuring hard PVC cylindrical chambers and one that features soft silicone chambers which are anatomically analogous to the native heart. We show that both MCLs are capable of simulating the onset of HFpEF with a sustained increase in diastolic pressure of 62.03% and a sustained decrease in end diastolic volume (EDV) of 14.24%.
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- [1] Evaluation and management of heart failure with preserved ejection fraction[J]. NATURE REVIEWS CARDIOLOGY, 2020, 17 (09) : 559 - 573Borlaug, Barry A.论文数: 0 引用数: 0 h-index: 0机构: Mayo Clin, Dept Cardiovasc Med, Rochester, MN 55905 USA Mayo Clin, Dept Cardiovasc Med, Rochester, MN 55905 USA
- [2] The pathophysiology of heart failure with preserved ejection fraction[J]. NATURE REVIEWS CARDIOLOGY, 2014, 11 (09) : 507 - 515Borlaug, Barry A.论文数: 0 引用数: 0 h-index: 0机构: Mayo Clin, Coll Med, Dept Med, Div Cardiovasc Dis, Rochester, MN 55905 USA Mayo Clin, Coll Med, Dept Med, Div Cardiovasc Dis, Rochester, MN 55905 USA
- [3] Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment[J]. EUROPEAN HEART JOURNAL, 2011, 32 (06) : 670 - +Borlaug, Barry A.论文数: 0 引用数: 0 h-index: 0机构: Mayo Clin Rochester, Dept Med, Div Cardiovasc Med, Rochester, MN 55905 USA Mayo Clin Rochester, Dept Med, Div Cardiovasc Med, Rochester, MN 55905 USAPaulus, Walter J.论文数: 0 引用数: 0 h-index: 0机构: Vrije Univ Amsterdam Med Ctr, Amsterdam, Netherlands Mayo Clin Rochester, Dept Med, Div Cardiovasc Med, Rochester, MN 55905 USA
- [4] Left Atrial Decompression Pump for Severe Heart Failure With Preserved Ejection Fraction Theoretical and Clinical Considerations[J]. JACC-HEART FAILURE, 2015, 3 (04) : 275 - 282论文数: 引用数: h-index:机构:Maurer, Mathew S.论文数: 0 引用数: 0 h-index: 0机构: Columbia Univ, Div Cardiol, New York, NY 10032 USA HeartWare Int, Framingham, MA USAJoseph, Susan M.论文数: 0 引用数: 0 h-index: 0机构: Washington Univ, Div Cardiol, St Louis, MO USA HeartWare Int, Framingham, MA USARogers, Joseph G.论文数: 0 引用数: 0 h-index: 0机构: Duke Univ, Div Cardiol, Durham, NC USA HeartWare Int, Framingham, MA USABirati, Edo Y.论文数: 0 引用数: 0 h-index: 0机构: Univ Penn, Div Cardiol, Philadelphia, PA 19104 USA HeartWare Int, Framingham, MA USARame, J. Eduardo论文数: 0 引用数: 0 h-index: 0机构: Univ Penn, Div Cardiol, Philadelphia, PA 19104 USA HeartWare Int, Framingham, MA USAShah, Sanjiv J.论文数: 0 引用数: 0 h-index: 0机构: Northwestern Univ, Div Cardiol, Chicago, IL 60611 USA HeartWare Int, Framingham, MA USA
- [5] The ethics of animal research - Talking Point on the use of animals in scientific research[J]. EMBO REPORTS, 2007, 8 (06) : 526 - 530Festing, Simon论文数: 0 引用数: 0 h-index: 0机构: Res Def Soc, London, England Res Def Soc, London, EnglandWilkinson, Robin论文数: 0 引用数: 0 h-index: 0机构: Res Def Soc, London, England Res Def Soc, London, England
- [6] Left atrial assist device to treat patients with heart failure with preserved ejection fraction: Initial in vitro study[J]. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2021, 162 (01) : 120 - 126Fukamachi, Kiyotaka论文数: 0 引用数: 0 h-index: 0机构: Cleveland Clin, Dept Biomed Engn, Lerner Res Inst, Cleveland, OH 44106 USA Cleveland Clin, Dept Biomed Engn, Lerner Res Inst, Cleveland, OH 44106 USAHorvath, David J.论文数: 0 引用数: 0 h-index: 0机构: R1 Engn, Euclid, OH USA Cleveland Clin, Dept Biomed Engn, Lerner Res Inst, Cleveland, OH 44106 USAKarimov, Jamshid H.论文数: 0 引用数: 0 h-index: 0机构: Cleveland Clin, Dept Biomed Engn, Lerner Res Inst, Cleveland, OH 44106 USA Cleveland Clin, Dept Biomed Engn, Lerner Res Inst, Cleveland, OH 44106 USAKado, Yuichiro论文数: 0 引用数: 0 h-index: 0机构: Cleveland Clin, Dept Biomed Engn, Lerner Res Inst, Cleveland, OH 44106 USA Cleveland Clin, Dept Biomed Engn, Lerner Res Inst, Cleveland, OH 44106 USAMiyamoto, Takuma论文数: 0 引用数: 0 h-index: 0机构: Cleveland Clin, Dept Biomed Engn, Lerner Res Inst, Cleveland, OH 44106 USA Cleveland Clin, Dept Biomed Engn, Lerner Res Inst, Cleveland, OH 44106 USAKuban, Barry D.论文数: 0 引用数: 0 h-index: 0机构: Cleveland Clin, Dept Biomed Engn, Lerner Res Inst, Cleveland, OH 44106 USA Lerner Res Inst, Elect Core, Med Device Solut, Cleveland, OH USA Cleveland Clin, Dept Biomed Engn, Lerner Res Inst, Cleveland, OH 44106 USAStarling, Randall C.论文数: 0 引用数: 0 h-index: 0机构: Miller Family Heart & Vasc Inst, Dept Cardiovasc Med, Cleveland, OH USA Cleveland Clin, Kaufman Ctr Heart Failure, Cleveland, OH 44106 USA Cleveland Clin, Dept Biomed Engn, Lerner Res Inst, Cleveland, OH 44106 USA
- [7] A Valveless Pulsatile Pump for the Treatment of Heart Failure with Preserved Ejection Fraction: A Simulation Study[J]. CARDIOVASCULAR ENGINEERING AND TECHNOLOGY, 2019, 10 (01) : 69 - 79Granegger, Marcus论文数: 0 引用数: 0 h-index: 0机构: Univ Childrens Hosp Zurich, Pediat Heart Ctr, Dept Surg, Pediat Cardiovasc Surg, Zurich, Switzerland Univ Childrens Hosp Zurich, Childrens Res Ctr, Zurich, Switzerland Univ Childrens Hosp Zurich, Pediat Heart Ctr, Dept Surg, Pediat Cardiovasc Surg, Zurich, SwitzerlandDave, Hitendu论文数: 0 引用数: 0 h-index: 0机构: Univ Childrens Hosp Zurich, Pediat Heart Ctr, Dept Surg, Pediat Cardiovasc Surg, Zurich, Switzerland Univ Childrens Hosp Zurich, Childrens Res Ctr, Zurich, Switzerland Univ Childrens Hosp Zurich, Pediat Heart Ctr, Dept Surg, Pediat Cardiovasc Surg, Zurich, SwitzerlandKnirsch, Walter论文数: 0 引用数: 0 h-index: 0机构: Univ Childrens Hosp Zurich, Dept Surg, Pediat Heart Ctr, Pediat Cardiol, Zurich, Switzerland Univ Childrens Hosp Zurich, Childrens Res Ctr, Zurich, Switzerland Univ Childrens Hosp Zurich, Pediat Heart Ctr, Dept Surg, Pediat Cardiovasc Surg, Zurich, SwitzerlandThamsen, Bente论文数: 0 引用数: 0 h-index: 0机构: Univ Childrens Hosp Zurich, Pediat Heart Ctr, Dept Surg, Pediat Cardiovasc Surg, Zurich, Switzerland Univ Childrens Hosp Zurich, Childrens Res Ctr, Zurich, Switzerland Univ Childrens Hosp Zurich, Pediat Heart Ctr, Dept Surg, Pediat Cardiovasc Surg, Zurich, SwitzerlandSchweiger, Martin论文数: 0 引用数: 0 h-index: 0机构: Univ Childrens Hosp Zurich, Pediat Heart Ctr, Dept Surg, Pediat Cardiovasc Surg, Zurich, Switzerland Univ Childrens Hosp Zurich, Childrens Res Ctr, Zurich, Switzerland Univ Childrens Hosp Zurich, Pediat Heart Ctr, Dept Surg, Pediat Cardiovasc Surg, Zurich, SwitzerlandHubler, Michael论文数: 0 引用数: 0 h-index: 0机构: Univ Childrens Hosp Zurich, Pediat Heart Ctr, Dept Surg, Pediat Cardiovasc Surg, Zurich, Switzerland Univ Childrens Hosp Zurich, Childrens Res Ctr, Zurich, Switzerland Univ Childrens Hosp Zurich, Pediat Heart Ctr, Dept Surg, Pediat Cardiovasc Surg, Zurich, Switzerland
- [8] Forecasting the Impact of Heart Failure in the United States A Policy Statement From the American Heart Association[J]. CIRCULATION-HEART FAILURE, 2013, 6 (03) : 606 - 619Heidenreich, Paul A.论文数: 0 引用数: 0 h-index: 0机构: Stanford Univ, Stanford, CA 94305 USA Stanford Univ, Stanford, CA 94305 USAAlbert, Nancy M.论文数: 0 引用数: 0 h-index: 0机构: Cleveland Clin Fdn, Cleveland, OH USA Stanford Univ, Stanford, CA 94305 USAAllen, Larry A.论文数: 0 引用数: 0 h-index: 0机构: Univ Colorado, Boulder, CO 80309 USA Stanford Univ, Stanford, CA 94305 USABluemke, David A.论文数: 0 引用数: 0 h-index: 0机构: NIH, Bethesda, MD USA Stanford Univ, Stanford, CA 94305 USAButler, Javed论文数: 0 引用数: 0 h-index: 0机构: Emory Univ, Atlanta, GA 30322 USA Stanford Univ, Stanford, CA 94305 USAFonarow, Gregg C.论文数: 0 引用数: 0 h-index: 0机构: Univ Calif Los Angeles, Los Angeles, CA 90024 USA Stanford Univ, Stanford, CA 94305 USAIkonomidis, John S.论文数: 0 引用数: 0 h-index: 0机构: Med Univ S Carolina, Charleston, SC USA Stanford Univ, Stanford, CA 94305 USAKhavjou, Olga论文数: 0 引用数: 0 h-index: 0机构: RTI, Res Triangle Pk, NC USA Stanford Univ, Stanford, CA 94305 USAKonstam, Marvin A.论文数: 0 引用数: 0 h-index: 0机构: Tufts Med Ctr, Boston, MA USA Stanford Univ, Stanford, CA 94305 USAMaddox, Thomas M.论文数: 0 引用数: 0 h-index: 0机构: Stanford Univ, Stanford, CA 94305 USANichol, Graham论文数: 0 引用数: 0 h-index: 0机构: Univ Washington, Harborview Med Ctr, Seattle, WA 98195 USA Stanford Univ, Stanford, CA 94305 USAPham, Michael论文数: 0 引用数: 0 h-index: 0机构: Stanford Univ, Stanford, CA 94305 USAPina, Ileana L.论文数: 0 引用数: 0 h-index: 0机构: Montefiore Einstein Med Ctr, Bronx, NY USA Stanford Univ, Stanford, CA 94305 USATrogdon, Justin G.论文数: 0 引用数: 0 h-index: 0机构: RTI, Res Triangle Pk, NC USA Stanford Univ, Stanford, CA 94305 USA
- [9] Investigating the physiology of normothermic ex vivo heart perfusion in an isolated slaughterhouse porcine model used for device testing and training[J]. BMC CARDIOVASCULAR DISORDERS, 2019, 19 (01)Kappler, Benjamin论文数: 0 引用数: 0 h-index: 0机构: Univ Amsterdam, Dept Cardiothorac Surg, Med Ctr, Meibergdreef 9, Amsterdam, Netherlands LifeTec Grp BV, Eindhoven, Netherlands Univ Amsterdam, Dept Cardiothorac Surg, Med Ctr, Meibergdreef 9, Amsterdam, NetherlandsLedezma, Carlos A.论文数: 0 引用数: 0 h-index: 0机构: UCL, Dept Mech Engn, Torrington Pl, London, England Univ Amsterdam, Dept Cardiothorac Surg, Med Ctr, Meibergdreef 9, Amsterdam, Netherlandsvan Tuijl, Sjoerd论文数: 0 引用数: 0 h-index: 0机构: LifeTec Grp BV, Eindhoven, Netherlands Univ Amsterdam, Dept Cardiothorac Surg, Med Ctr, Meibergdreef 9, Amsterdam, NetherlandsMeijborg, Veronique论文数: 0 引用数: 0 h-index: 0机构: Univ Amsterdam, Dept Med Biol, Med Ctr, Meibergdreef 9, Amsterdam, Netherlands Univ Amsterdam, Dept Cardiothorac Surg, Med Ctr, Meibergdreef 9, Amsterdam, NetherlandsBoukens, Bastiaan J.论文数: 0 引用数: 0 h-index: 0机构: Univ Amsterdam, Dept Med Biol, Med Ctr, Meibergdreef 9, Amsterdam, Netherlands Univ Amsterdam, Dept Cardiothorac Surg, Med Ctr, Meibergdreef 9, Amsterdam, NetherlandsErgin, Bulent论文数: 0 引用数: 0 h-index: 0机构: Univ Amsterdam, Dept Translat Physiol, Med Ctr, Meibergdreef 9, Amsterdam, Netherlands Univ Amsterdam, Dept Cardiothorac Surg, Med Ctr, Meibergdreef 9, Amsterdam, NetherlandsTan, P. J.论文数: 0 引用数: 0 h-index: 0机构: UCL, Dept Mech Engn, Torrington Pl, London, England Univ Amsterdam, Dept Cardiothorac Surg, Med Ctr, Meibergdreef 9, Amsterdam, NetherlandsStijnen, Marco论文数: 0 引用数: 0 h-index: 0机构: LifeTec Grp BV, Eindhoven, Netherlands Univ Amsterdam, Dept Cardiothorac Surg, Med Ctr, Meibergdreef 9, Amsterdam, NetherlandsInce, Can论文数: 0 引用数: 0 h-index: 0机构: Univ Amsterdam, Dept Translat Physiol, Med Ctr, Meibergdreef 9, Amsterdam, Netherlands Univ Amsterdam, Dept Cardiothorac Surg, Med Ctr, Meibergdreef 9, Amsterdam, NetherlandsDiaz-Zuccarini, Vanessa论文数: 0 引用数: 0 h-index: 0机构: UCL, Dept Mech Engn, Torrington Pl, London, England UCL, WEISS Ctr Surg & Intervent Sci, Gower St 10, London, England Univ Amsterdam, Dept Cardiothorac Surg, Med Ctr, Meibergdreef 9, Amsterdam, Netherlandsde Mol, Bas A. J. M.论文数: 0 引用数: 0 h-index: 0机构: Univ Amsterdam, Dept Cardiothorac Surg, Med Ctr, Meibergdreef 9, Amsterdam, Netherlands LifeTec Grp BV, Eindhoven, Netherlands Univ Amsterdam, Dept Cardiothorac Surg, Med Ctr, Meibergdreef 9, Amsterdam, Netherlands
- [10] Diastolic pressure-volume quotient (DPVQ) as a novel echocardiographic index for estimation of LV stiffness in HFpEF[J]. CLINICAL RESEARCH IN CARDIOLOGY, 2015, 104 (11) : 955 - 963Kasner, Mario论文数: 0 引用数: 0 h-index: 0机构: Charite, Dept Cardiol, D-13353 Berlin, Germany Charite, Dept Cardiol, D-13353 Berlin, GermanySinning, David论文数: 0 引用数: 0 h-index: 0机构: Charite, Dept Cardiol, D-13353 Berlin, Germany Charite, Dept Cardiol, D-13353 Berlin, Germany论文数: 引用数: h-index:机构:Tschoepe, Carsten论文数: 0 引用数: 0 h-index: 0机构: Charite, Dept Cardiol, D-13353 Berlin, Germany Charite, Berlin Brandenburg Ctr Regenerat Therapies, D-13353 Berlin, Germany German Ctr Cardiovasc Res DZHK, Hamburg, Germany Charite, Dept Cardiol, D-13353 Berlin, Germany