Copper-catalyzed C-H alkylation of 8-aminoquinolines via 8-amide chelation assistance

被引：31

作者：

Xia, Xiao-Feng ^{[1
]}

Zhu, Su-Li ^{[1
]}

Gu, Zhen ^{[1
]}

Wang, Haijun ^{[1
]}

机构：

[1] Jiangnan Univ, Sch Chem & Mat Engn, Minist Educ, Key Lab Food Colloids & Biotechnol, Wuxi 214122, Jiangsu, Peoples R China

来源：

RSC ADVANCES | 2015年 / 5卷 / 37期

基金：

美国国家科学基金会;

关键词：

QUINOLINE N-OXIDES; ALIPHATIC CARBOXYLIC-ACIDS; ALPHA-AMINO-ACIDS; MILD CONDITIONS; ARYL HALIDES; DIRECTING GROUP; C-8; POSITION; ARYLATION; AGENTS; ANTIMALARIALS;

D O I：

10.1039/c4ra16896h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A copper-catalyzed 8-amide chelation- assisted C-H alkylation of 8-aminoquinolines is described. The secondary and tertiary alkyl carboxylic acids can be used as alkylating agents. This reaction allows for the highly regioselective preparation of C2-adamantyl 8-aminoquinoline scaffolds by the decarboxylative alkylation catalytic system.

引用

页码：28892 / 28895

页数：4

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