Ependymoma with neuropil-like islands: a case report with diagnostic and histogenetic implications

被引:29
作者
Gessi, M
Marani, C
Geddes, J
Arcella, A
Cenacchi, G
Giangaspero, F
机构
[1] Policlin Umberto 1, I-00161 Rome, Italy
[2] Univ Roma La Sapienza, Dept Expt Med & Pathol, Rome, Italy
[3] IRCCS Neuromed, Pozzilli, Italy
[4] Royal London Hosp, Dept Histopathol & Morbid Anat, London E1 1BB, England
[5] Univ Bologna, Dept Radiol & Pathol, Bologna, Italy
关键词
ependymoma; neuropil-like islands; neurocytic differentiation;
D O I
10.1007/s00401-004-0927-y
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We describe a case of ependymoma with neuronal differentiation in form of neuropil-like islands. A 6-year-old boy presented at clinical examination for a short history of headaches and vomiting. Brain computed tomography showed a large, partially cystic, parieto-occipital lesion. The tumor was composed by glial fibrillary acidic protein-positive round cells with a perivascular arrangement and scattered neuropil-like islands, showing intense positivity for synaptophysin. Despite radiotherapy, the tumor recurred, showing frank features of anaplasia, but lacking the neuropil-like islands. The histological features of the tumor are discussed in the light of the concept that neuronal differentiation can occur occasionally in gliomas of different lineage without affecting the expected biological behavior.
引用
收藏
页码:231 / 234
页数:4
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