共 215 条
Transcription factor-mediated reprogramming toward hematopoietic stem cells
被引:35
作者:

Ebina, Wataru
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h-index: 0
机构:
Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA
Boston Childrens Hosp, Div Hematol Oncol, Program Cellular & Mol Med, Boston, MA USA Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA

Rossi, Derrick J.
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h-index: 0
机构:
Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA
Boston Childrens Hosp, Div Hematol Oncol, Program Cellular & Mol Med, Boston, MA USA
Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA
Harvard Stem Cell Inst, Cambridge, MA USA Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA
机构:
[1] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA
[2] Boston Childrens Hosp, Div Hematol Oncol, Program Cellular & Mol Med, Boston, MA USA
[3] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA
[4] Harvard Stem Cell Inst, Cambridge, MA USA
关键词:
cell fate conversion;
hematopoietic stem cells;
induced reprogramming;
transcription factors;
ACUTE MYELOID-LEUKEMIA;
ACUTE LYMPHOBLASTIC-LEUKEMIA;
ADULT-MOUSE HEMATOPOIESIS;
GROUND-STATE PLURIPOTENCY;
REGULATES SELF-RENEWAL;
MODIFIED MESSENGER-RNA;
HUMAN FIBROBLASTS;
PROGENITOR CELLS;
DEFINED FACTORS;
IN-VIVO;
D O I:
10.15252/embj.201490804
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
De novo generation of human hematopoietic stem cells (HSCs) from renewable cell types has been a long sought-after but elusive goal in regenerative medicine. Paralleling efforts to guide pluripotent stem cell differentiation by manipulating developmental cues, substantial progress has been made recently toward HSC generation via combinatorial transcription factor (TF)-mediated fate conversion, a paradigm established by Yamanaka's induction of pluripotency in somatic cells by mere four TFs. This review will integrate the recently reported strategies to directly convert a variety of starting cell types toward HSCs in the context of hematopoietic transcriptional regulation and discuss how these findings could be further developed toward the ultimate generation of therapeutic human HSCs.
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页码:694 / 709
页数:16
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