Occurrence of conjugative IncF-type plasmids harboring the blaCTX-M-15 gene in Enterobacteriaceae isolates from newborns in Tunisia

被引：11
|
作者：
Lahlaoui, Hella [1 ]
De Luca, Filomena [2 ]
Maradel, Simona [2 ]
Ben-Haj-Khalifa, Anis [3 ]
Ben Hamouda, Hechmi [3 ]
Kheder, Mohamed [3 ]
Ben Moussa, Mohamed [1 ]
Rossillini, Gian-Maria [2 ]
Docquier, Jean-Denis [2 ]
机构：
[1] Mil Hosp Tunis, Microbiol Lab, Monfleury, Tunisia
[2] Univ Siena, Dept Med Biotechnol, I-53100 Siena, Italy
[3] Hosp Tahar Sfar, Microbiol Lab, Mahdia, Tunisia
来源：
PEDIATRIC RESEARCH | 2015年 / 77卷 / 01期
关键词：
SPECTRUM BETA-LACTAMASES; CTX-M-TYPE; COMPLETE NUCLEOTIDE-SEQUENCE; ESCHERICHIA-COLI; KLEBSIELLA-PNEUMONIAE; ADDICTION SYSTEMS; DISSEMINATION; CTX-M-15; STRAINS; PREVALENCE;
D O I：
10.1038/pr.2014.153
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
BACKGROUND: CTX-M-15 is the dominant type of extended-spectrum beta-lactamase in clinical isolates. This enzyme constitutes the most widespread enzymes in Tunisia. In this study, we were interested to understand the causes of the evolutionary success of CTX-M-15 in a Tunisian university hospital. METHODS: A total of of 72 cefotaxime-resistant Enterobacteriaceae were isolated from newborn patients at the hospital Taher sfar Mandia in Tunisia and characterized their genetic support by means of molecular techniques. RESULTS: Isolates were clustered into various clonal groups, although most isolates belonged to sequence types ST39 (Klebsiella pneumoniae) and ST131 (Escherichia coli). F replicons (FIA, FIB, and Fit) were the most frequently detected replicon types in our collection (91.66%). CONCLUSION: This is the first report of QnrB- and CTX-M-15-encoding large IncF-type conjugative plasmids in Tunisia.
引用
收藏
页码：107 / 110
页数：4
相关论文
共 38 条
  • [31] High Prevalence of blaCTX-M Extended Spectrum Beta-Lactamase Genes in Klebsiella pneumoniae Isolates from a Tertiary Care Hospital: First report of blaSHV-12, blaSHV-31, blaSHV-38, and blaCTX-M-15 in Brazil
    Tollentino, Fernanda M.
    Polotto, Milena
    Nogueira, Mauricio L.
    Lincopan, Nilton
    Neves, Patricia
    Mamizuka, Elsa M.
    Remeli, Gisele A.
    De Almeida, Margarete T. G.
    Rubio, Fernando G.
    Nogueira, Mara C. L.
    MICROBIAL DRUG RESISTANCE, 2011, 17 (01) : 7 - 16
  • [32] Differential effects of chromosome and plasmid blaCTX-M-15 genes on antibiotic susceptibilities in extended-spectrum beta-lactamase-producing Escherichia coli isolates from patients with urinary tract infection
    Yang, Young-min
    Osawa, Kayo
    Kitagawa, Koichi
    Hosoya, Samiko
    Onishi, Reo
    Ishii, Aya
    Shirakawa, Toshiro
    Hirai, Itaru
    Kuntaman, Kuntaman
    Tanimoto, Hiroshi
    Shigemura, Katsumi
    Fujisawa, Masato
    INTERNATIONAL JOURNAL OF UROLOGY, 2021, 28 (06) : 623 - 628
  • [33] RETRACTED: A Plasmid Bearing the blaCTX-M-15 Gene and Phage P1-Like Sequences from a Sequence Type 11 Klebsiella pneumoniae Isolate (Retracted article. See vol. 66, 2022)
    Shin, Juyoun
    Ko, Kwan Soo
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2015, 59 (10) : 6608 - 6610
  • [34] IS26-Flanked Composite Transposon Tn6539 Carrying the tet(M) Gene in IncHI2-Type Conjugative Plasmids From Escherichia coli Isolated From Ducks in China
    Sun, Ya-wei
    Liu, Ying-ying
    Wu, Hua
    Wang, Ling-fei
    Liu, Jian-hua
    Yuan, Li
    Pan, Yu-shan
    He, Dan-dan
    Hu, Gong-zheng
    FRONTIERS IN MICROBIOLOGY, 2019, 9
  • [35] F33:A-:B- and F2:A-:B- Plasmids Mediate Dissemination of rmtB-blaCTX-M-9 Group Genes and rmtB-qepA in Enterobacteriaceae Isolates from Pets in China
    Deng, Yuting
    He, Liangying
    Chen, Sheng
    Zheng, Hongqing
    Zeng, Zhenling
    Liu, Yahong
    Sun, Yan
    Ma, Junying
    Chen, Zhangliu
    Liu, Jian-Hua
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2011, 55 (10) : 4926 - 4929
  • [36] Occurrence of the Plasmid-Mediated Fluoroquinolone Resistance qepA1 Gene in Two Clonal Clinical Isolates of CTX-M-15-Producing Escherichia coli from Algeria
    Yanat, Betitera
    Yahia, Radia Dali
    Yazi, Leila
    Machuca, Jesus
    Diaz-De-Alba, Paula
    Touati, Abdelaziz
    Pascual, Alvaro
    Rodriguez-Martinez, Jose-Manuel
    MICROBIAL DRUG RESISTANCE, 2017, 23 (04) : 497 - 499
  • [37] Molecular Epidemiological Analysis of Escherichia coli Sequence Type ST131 (O25:H4) and blaCTX-M-15 among Extended-Spectrum-β- Lactamase-Producing E. coli from the United States, 2000 to 2009
    Johnson, James R.
    Urban, Carl
    Weissman, Scott J.
    Jorgensen, James H.
    Il, James S. Lewis
    Hansen, Glen
    Edelstein, Paul H.
    Robicsek, Ari
    Cleary, Timothy
    Adachi, Javier
    Paterson, David
    Quinn, John
    Hanson, Nancy D.
    Johnston, Brian D.
    Clabots, Connie
    Kuskowski, Michael A.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2012, 56 (05) : 2364 - 2370
  • [38] A putative multi-replicon plasmid co-harboring beta-lactamase genes blaKPC-2, blaCTX-M-14 and blaTEM-1 and trimethoprim resistance gene dfrA25 from a Klebsiella pneumoniae sequence type (ST) 11 strain in China
    Tang, Yu
    Shen, Pinghua
    Liang, Wei
    Jin, Jialin
    Jiang, Xiaofei
    PLOS ONE, 2017, 12 (02):
1234