Clustering Nuclear Magnetic Resonance: Machine learning assistive rapid two-dimensional relaxometry mapping

被引:16
作者
Peng, Weng Kung [1 ]
机构
[1] Int Iberian Nanotechnol Lab, Precis Med, Engn Grp, Braga, Portugal
关键词
clustering NMR; machine learning; n-dimensionality; rapid and accurate classification; SOLID-STATE NMR; CROSS-POLARIZATION; METABOLOMICS; CHIP;
D O I
10.1002/eng2.12383
中图分类号
TP39 [计算机的应用];
学科分类号
081203 ; 0835 ;
摘要
Low-field nuclear magnetic resonance (NMR) relaxometry is an attractive approach from point-of-care testing medical diagnosis to in situ oil-gas exploration. One of the problems, however, is the inherently long relaxation time of the (liquid) samples, (and hence low signal-to-noise ratio) which causes unnecessarily long repetition time. In this work, a new class of methodology is presented for rapid and accurate object classification using NMR relaxometry with the aid of machine learning. It is demonstrated that the sensitivity and specificity of the classification is substantially improved with higher order of (pseudo)-dimensionality (e.g., 2D- or multi-dimensional). This new methodology (termed as 'Clustering NMR') may be extremely useful for rapid and accurate object classification (in less than a minute) using low-field NMR.
引用
收藏
页数:11
相关论文
共 60 条
  • [1] Ultrafast multidimensional Laplace NMR for a rapid and sensitive chemical analysis
    Ahola, Susanna
    Zhivonitko, Vladimir V.
    Mankinen, Otto
    Zhang, Guannan
    Kantola, Anu M.
    Chen, Hsueh-Ying
    Hilty, Christian
    Koptyug, Igor V.
    Telkki, Ville-Veikko
    [J]. NATURE COMMUNICATIONS, 2015, 6
  • [2] An Integrated CMOS Receiver Chip for NMR-Applications
    Anders, Jens
    SanGiorgio, Paul
    Boero, Giovanni
    [J]. PROCEEDINGS OF THE IEEE 2009 CUSTOM INTEGRATED CIRCUITS CONFERENCE, 2009, : 471 - 474
  • [3] [Anonymous], 2011, Patent No. [US10429467B2, 10429467]
  • [4] Nuclear magnetic resonance-based screening of thalassemia and quantification of some hematological parameters using chemometric methods
    Arjmand, Mohammad
    Kompany-Zareh, Mohsen
    Vasighi, Mandi
    Parvizzadeh, Nastran
    Zamani, Zahra
    Nazgooei, Fereshteh
    [J]. TALANTA, 2010, 81 (4-5) : 1229 - 1236
  • [5] Novel 1H low field nuclear magnetic resonance applications for the field of biodiesel
    Berman, Paula
    Leshem, Adi
    Etziony, Oren
    Levi, Ofer
    Parmet, Yisrael
    Saunders, Michael
    Wiesman, Zeev
    [J]. BIOTECHNOLOGY FOR BIOFUELS, 2013, 6
  • [6] Laplace Inversion of Low-Resolution NMR Relaxometry Data Using Sparse Representation Methods
    Berman, Paula
    Levi, Ofer
    Parmet, Yisrael
    Saunders, Michael
    Wiesman, Zeev
    [J]. CONCEPTS IN MAGNETIC RESONANCE PART A, 2013, 42 (03) : 72 - 88
  • [7] Chemometric Methods for Spectroscopy-Based Pharmaceutical Analysis
    Biancolillo, Alessandra
    Marini, Federico
    [J]. FRONTIERS IN CHEMISTRY, 2018, 6
  • [8] Multivariate Analysis Relating Oil Shale Geochemical Properties to NMR Relaxometry
    Birdwell, Justin E.
    Washburn, Kathryn E.
    [J]. ENERGY & FUELS, 2015, 29 (04) : 2234 - 2243
  • [9] NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition
    Bollard, ME
    Stanley, EG
    Lindon, JC
    Nicholson, JK
    Holmes, E
    [J]. NMR IN BIOMEDICINE, 2005, 18 (03) : 143 - 162
  • [10] Miniaturized nuclear magnetic resonance platform for detection and profiling of circulating tumor cells
    Castro, Cesar M.
    Ghazani, Arezou A.
    Chung, Jaehoon
    Shao, Huilin
    Issadore, David
    Yoon, Tae-Jong
    Weissleder, Ralph
    Lee, Hakho
    [J]. LAB ON A CHIP, 2014, 14 (01) : 14 - 23