Stem cell mechanisms and paracrine effects: Potential in cardiac surgery

被引：54
作者：
Crisostomo, Paul R.
Wang, Meijing
Markel, Troy A.
Lahm, Tim
Abarbanell, Aaron M.
Herrmann, Jeremy L.
Meldrum, Daniel R.
机构：
[1] Indiana Univ, Sch Med, Dept Surg, Indianapolis, IN 46202 USA
[2] Indiana Univ, Sch Med, Dept Physiol, Indianapolis, IN 46202 USA
[3] Indiana Univ, Sch Med, Dept Med, Indianapolis, IN 46202 USA
[4] Indiana Univ, Sch Med, Ctr Immunobiol, Indianapolis, IN 46202 USA
来源：
SHOCK | 2007年 / 28卷 / 04期
关键词：
cardioprotection; HGF; mesenchymal; MSC; signaling; VEGF;
D O I：
10.1097/shk.0b013e318058a817
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Heart disease remains the leading cause of death in the industrialized world. Stem cell therapy is a promising treatment modality for injured cardiac tissue. A novel mechanism for this cardioprotection may include paracrine actions. Cardiac surgery represents the unique situation where preischemia and postischemia treatment modalities exist that may use stem cell paracrine protection. This review (1) recalls the history of stem cells in cardiac disease and the unraveling of its mechanistic basis for protection, (2) outlines the pathways for stem cell-mediated paracrine protection, (3) highlights the signaling factors expressed, (4) explores the potential of using stem cells clinically in cardiac surgery, and (5) summarizes all human stem cell studies in cardiac disease to date.
引用
收藏
页码：375 / 383
页数：9
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