Application of stem cell transplantation in autoimmune diseases

被引：14

作者：

Ng, Sue-Ann ^{[1
]}

Sullivan, Keith M. ^{[2
]}

机构：

[1] Singapore Gen Hosp, Dept Rheumatol & Immunol, Singapore, Singapore

[2] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

来源：

CURRENT OPINION IN HEMATOLOGY | 2019年 / 26卷 / 06期

关键词：

autoimmune diseases; autologous hematopoietic stem cell transplantation; stem cell transplantation; DOSE IMMUNOSUPPRESSIVE THERAPY; REMITTING MULTIPLE-SCLEROSIS; BONE-MARROW-TRANSPLANTATION; TERM-FOLLOW-UP; SYSTEMIC-SCLEROSIS; EUROPEAN GROUP; PULSE CYCLOPHOSPHAMIDE; BLOOD; OUTCOMES; MORTALITY;

D O I：

10.1097/MOH.0000000000000531

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of review Autologous hematopoietic stem cell transplantation (HSCT) is a promising therapeutic modality for severe autoimmune diseases. In this review, we will outline the immunological mechanisms and the clinical evidence and experiences for therapeutic HSCT in autoimmune diseases, with particular focus on systemic sclerosis and multiple sclerosis. Recent findings Approximately 3000 patients with autoimmune diseases worldwide have been treated with HSCT. HSCT in systemic sclerosis has been shown in three randomized controlled trials to be associated with significant long-term event-free survival despite some transplant-related mortality in the first year. A recent controlled trial in multiple sclerosis has also show benefit with transplant. The aim of HSCT is to 'reset' one's immune system into a naive and self-tolerant state through immune depletion and regulation. HSCT requires careful patient selection, close collaboration between physicians and expertise of transplant team to ensure optimal outcome.

引用

页码：392 / 398

页数：7

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