Catecholamines and their metabolites in the brain and urine of rats with experimental Parkinson's disease

被引：15

作者：

Chekhonin, VP ^{[1
]}

Baklaushev, VP ^{[1
]}

Kogan, BM ^{[1
]}

Savchenko, EA ^{[1
]}

Lebedev, SV ^{[1
]}

Man'kovskaya, IV ^{[1
]}

Filatova, TS ^{[1
]}

Yusupova, IU ^{[1
]}

Dmitrieva, TB ^{[1
]}

机构：

[1] VP Serbskii State Ctr Social & Forens Psychiat, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2000年 / 130卷 / 08期

关键词：

experimental parkinsonism; catecholamines;

D O I：

10.1007/BF02681952

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The content of catecholamines and their metabolites in the brain and the relationship between cerebral catecholamine levels and their urinary excretion were studied in rats with 6-OHDA-induced hemiparkinsonism. 6-OHDA reduced brain concentrations of dopamine, DOPAC, and homovanilic acid and urinary excretion of dopamine, dioxyphenilalanine, and DOPAC by more than 90%. A positive correlation was found between the concentrations of these metabolites in the urine and striatum. Measurement of urinary catecholamines and their metabolites is a perspective test for evaluating the status of the dopaminergic nigrosostriate system of the brain in experimental parkinsonism.

引用

页码：805 / 809

页数：5

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